Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins.

Infection and Immunity
D E Van Epps, S L Brown

Abstract

Immunoglobulin A (IgA) paraproteins from patients with myeloma have been shown to inhibit human neutrophil chemotaxis to C5a, casein, and chemotactic factors produced by Escherichia coli. This study demonstrates that these paraproteins also inhibit neutrophil chemotaxis in response to the synthetic peptide formylmethionyl-leucyl-phenylalanine (f-MLP). Furthermore, the neutrophil chemiluminescence response stimulated by f-MLP was markedly suppressed by the presence of IgA paraprotein. Maximal inhibition of chemiluminescence was observed when the paraprotein was present during the chemiluminescence response. The inhibitory activity was substantially reduced by removal of the Fc region of IgA or by conversion of polymeric IgA to monomeric IgA by limited reduction and alkylation. Additional experiments showed that these IgA paraproteins inhibited C5a but not phorbol myristate acetate-stimulated chemiluminescence. These observations are constant with the hypothesis that polymeric forms of IgA bind to human neutrophils and interfere with the binding of chemotactic factor to its receptor or the consequent receptor-mediated oxidative burst or both.

References

Sep 1, 1979·Inflammation·K J ReedR C Williams
May 17, 1979·The New England Journal of Medicine·L Harvath, B R Andersen
Mar 15, 1978·Cellular Immunology·D E Van EppsR C Williams
Jan 1, 1978·The Journal of Experimental Medicine·G E HatchD B Menzel
Feb 1, 1975·Australian and New Zealand Journal of Medicine·J B ZieglerR Penny
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J RadlJ Mestecky
Nov 2, 1976·The Journal of Experimental Medicine·D E Van Epps, R C Williams
Jul 1, 1974·The Journal of Clinical Investigation·S Hauptman, T B Tomasi
Aug 1, 1980·The Journal of Clinical Investigation·D E Van Epps, M L Garcia

❮ Previous
Next ❯

Citations

Sep 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·J A Westman
Jun 1, 1985·Journal of Periodontology·L Sandholm
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianming WuRobert P Kimberly
Nov 17, 2009·Immunological Reviews·Ulrich BlankRenato C Monteiro
Jun 22, 2011·MAbs·Jantine E Bakema, Marjolein van Egmond
Jan 1, 1992·Immunologic Research·L Shen
Aug 1, 1982·Infection and Immunity·J S AbramsonD A Bass
Feb 1, 1989·Infection and Immunity·M ArashiJ P Vaerman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.