PMID: 7542175Jul 1, 1995Paper

Inhibition of gap junctional communication by polyunsaturated fatty acids in WB cells: evidence that connexin 43 is not hyperphosphorylated

Carcinogenesis
C S HiiA W Murray

Abstract

Polyunsaturated fatty acids have attracted much interest due to their wide spectrum of biological activities which include the modulation of gap junctional communication (GJC). Since gap junctions play critical roles in maintaining the functional integrity of organs and tissues, and loss of intercellular communication is associated with a number of pathological conditions, we investigated the effects of the n-6 and n-3 series of polyunsaturated fatty acids and their derivatives on GJC in WB cells as determined by the ability of Lucifer Yellow-loaded cells to transfer the dye to neighbouring recipient cells. Studies were also conducted to investigate the possible mechanisms of action of the fatty acids. Treatment of cells with 10 microM arachidonic acid (20:4 n-6) resulted in a rapid and transient loss of communication competence. The response to 20 microM 20:4 (n-6) was prolonged (> 210 min) but was readily reversible by washing the cells with fatty acid-free bovine serum albumin. Cells which had regained their communication competence responded to further additions of 20:4 (n-6). The fatty acids, 18:3 (n-6), 20:5 (n-3), 22:6 (n-3) and the 15-hydroxy- and the 15-hydroperoxy-derivatives of 20:4 (n-6) were also powerful inhibitor...Continue Reading

Citations

Jul 3, 1998·Critical Reviews in Oncology/hematology·W G JiangD F Horrobin
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J BrunoOlaf S Andersen
Feb 20, 2013·The Journal of Physiology·Alina MarandykinaFeliksas F Bukauskas
Sep 27, 2003·International Journal of Andrology·Silvina B MeroniSelva B Cigorraga
Dec 13, 2006·The European Journal of Neuroscience·Gaelle Champeil-PotokarIsabelle Denis
Nov 22, 2013·The Journal of Reproduction and Development·Ewelina WarzychDorota Lechniak
Feb 9, 2017·Frontiers in Physiology·Carlos PueblaJuan C Sáez
Apr 1, 2004·Journal of Cell Science·Takahiko OgawaNoriaki Yorioka
Aug 28, 2021·International Journal of Molecular Sciences·Iva SovadinováPavel Babica

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