PMID: 8962142Dec 10, 1996Paper

Inhibition of gastric acid secretion by stress: a protective reflex mediated by cerebral nitric oxide

Proceedings of the National Academy of Sciences of the United States of America
J V EspluguesS Moncada

Abstract

Moderate somatic stress inhibits gastric acid secretion. We have investigated the role of endogenously released NO in this phenomenon. Elevation of body temperature by 3 degrees C or a reduction of 35 mmHg (1 mmHg = 133 Pa) in blood pressure for 10 min produced a rapid and long-lasting reduction of distension-stimulated acid secretion in the rat perfused stomach in vivo. A similar inhibitory effect on acid secretion was produced by the intracisternal (i.c.) administration of oxytocin, a peptide known to be released during stress. Intracisternal administration of the NO-synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) reversed the antisecretory effect induced by all these stimuli, an action prevented by intracisternal coadministration of the NO precursor, L-arginine. Furthermore, microinjection of L-NAME into the dorsal motor nucleus of the vagus nerve reversed the acid inhibitory effects of mild hyperthermia, i.v. endotoxin, or i.c. oxytocin, an action prevented by prior microinjection of L-arginine. By contrast, microinjection of L-NAME into the nucleus tractus solitarius failed to affect the inhibitory effects of hyperthermia, i.v. endotoxin, or i.c. oxytocin. Immunohistochemical techniques demonstrated that foll...Continue Reading

References

Aug 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L GuesdonS Avrameas
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jan 1, 1985·Gastroenterology·G M AndersonD J Cohen
Aug 1, 1985·Gastroenterology·E Danquechin DorvalA Dubois
Jan 1, 1988·Canadian Journal of Physiology and Pharmacology·N W Kasting
Aug 22, 1985·The Journal of Comparative Neurology·R E Shapiro, R R Miselis
Oct 1, 1973·Physiology & Behavior·W P Paré, A Livingston
Nov 1, 1970·The American Journal of Physiology·R T Witty, J F Long
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·K MineT Nakagawa
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y TachéM Brown
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jul 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J RodrigoS Moncada
Nov 1, 1960·The American Journal of Digestive Diseases·R MENGUY

❮ Previous
Next ❯

Citations

May 29, 2001·Microscopy Research and Technique·S CalatayudJ V Esplugues
Feb 24, 2001·Journal of Physiology and Biochemistry·O Martínez-AugustínF Sánchez de Medina
Jun 7, 2005·Life Sciences·Elsa QuintanaMaría D Barrachina
Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Dec 16, 1998·Trends in Pharmacological Sciences·S LamasS Moncada
Aug 24, 1999·British Journal of Pharmacology·S CalatayudJ V Esplugues
Sep 21, 2001·British Journal of Pharmacology·E QuintanaM D Barrachina
Mar 6, 2002·British Journal of Pharmacology·Juan V Esplugues
Nov 7, 1998·Acta Physiologica Scandinavica·M MoleroJ Chacin
Nov 20, 1998·The Journal of Pharmacy and Pharmacology·S CalatayudJ V Esplugues
Jun 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ze-Feng XiaMichael W Mulholland
Jul 18, 2002·Japanese Journal of Pharmacology·Shizuko TsuchiyaKazuo Watanabe
Mar 31, 2011·World Journal of Gastroenterology : WJG·Noha N NassarDalaal M Abdallah
Feb 14, 2009·Journal of Gastroenterology·Seyyed Ali MardMohammad Badavi
Aug 16, 2002·The Journal of Physiology·Mark W LewisR Alberto Travagli
May 29, 2003·British Journal of Pharmacology·Sara CalatayudM Dolores Barrachina
Dec 16, 2006·The Journal of Clinical Hypertension·Thomas D Giles
Sep 3, 2009·Microscopy Research and Technique·Domenico RussoGiovanna Lalatta-Costerbosa
Nov 3, 2005·European Journal of Pharmacology·María E SabbatiniLiliana G Bianciotti
Jul 5, 2003·Biological & Pharmaceutical Bulletin·Ko HasebeKazuo Watanabe
Jan 17, 2003·The Journal of Biological Chemistry·Kaushik BiswasRanajit K Banerjee
Sep 2, 1998·The American Journal of Physiology·D W MercerD H Russell
Nov 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sara CalatayudMaría Dolores Barrachina
Nov 20, 2016·Digestive Diseases and Sciences·Larisse Tavares LucettiMarcellus Henrique Loiola Ponte Souza
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Aug 14, 2020·American Journal of Infection Control·Julia J Dibner
Aug 7, 2021·Frontiers in Pharmacology·Wout VerbeurePeter R van Dijk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.