PMID: 9953Dec 1, 1975

Inhibition of gastric emptying and drug absorption by narcotic analgesics

British Journal of Clinical Pharmacology
W S NimmoL F Prescott

Abstract

The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.

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