Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice

Biochemical and Biophysical Research Communications
Rei NaitohNobuya Inagaki

Abstract

Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation in peripheral tissues under high-fat diet (HFD), but the mechanism is unknown. In the present study, we investigated the effects of inhibition of GIP signaling on adiponectin levels after 3 weeks of HFD by comparing wild-type (WT) mice and GIP receptor-deficient (Gipr(-/-)) mice. In HFD-fed Gipr(-/-) mice, fat oxidation was significantly increased and adiponectin mRNA levels in white adipose tissue and plasma adiponectin levels were significantly increased compared to those in HFD-fed WT mice. In addition, the PPARalpha mRNA level was increased and the ACC mRNA level was decreased in skeletal muscle of HFD-fed Gipr(-/-) mice compared with those in HFD-fed WT mice. These results indicate that inhibition of GIP signaling increases adiponectin levels, resulting in increased fat oxidation in peripheral tissues under HFD.

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Citations

Jul 11, 2013·Obesity Surgery·Yuichiro KawanoSeigo Kitano
Apr 22, 2010·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe
Mar 18, 2013·Journal of Diabetes Investigation·Yutaka Seino, Daisuke Yabe
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Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Akira ShimotoyodomeTadashi Hase
Dec 5, 2012·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Nobuya Inagaki
Mar 2, 2021·American Journal of Physiology. Endocrinology and Metabolism·Geke Aline BoerMatthew J Watt
Jul 18, 2020·Current Topics in Medicinal Chemistry·Worood Sirhan, Ron Piran

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