PMID: 338406Dec 1, 1977Paper

Inhibition of glucagon release by serotonin in mouse pancreatic islets

Diabetologia
J MarcoM L Villanueva

Abstract

In this work we have investigated the effect of serotonin on glucagon release in mouse pancreatic islets isolated by the collagenase technique. Incubation of the islets with serotonin (4 X10(-3)mol/l) was associated with an inhibition of glucagon output both in the basal medium (3.3 mmol/l glucose) and in the presence of arginine (10 mmol/l). The inhibitory effect of serotonin on basal glucagon release was also apparent at concentrations of 2 X10(-3) mol/l, 10(-3)mol/l and 5 X 10(-4) mol/l. Addition of 5-hydroxytrypophan (4 X10(-3) mol/l) to the incubation medium was without effect on basal glucagon output while it significantly reduced arginine-induced glucagon release. In contrast, tryptophan (4 X10(-3) mol/l) provoked glucagon secretion. As inferred from our previous human studies, the present data indicate that serotonin is able to inhibit glucagon secretion. These findings provide further support for the participation of a serotoninergic mechanism in the control of A-cell function.

References

Feb 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J MarcoM L Villanueva
Oct 1, 1977·Metabolism: Clinical and Experimental·J A HedoJ Marco
Jan 1, 1970·Endocrinology·J M Feldman, H E Lebovitz
Jul 1, 1972·Diabetes·J M FeldmanH E Lebovitz
Sep 1, 1972·The Journal of Clinical Investigation·D M RochaR H Unger
Sep 1, 1971·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Lernmark
Nov 1, 1971·Endocrinology·K E QuickelH E Lebovitz
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher

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Citations

Jul 1, 1979·European Journal of Clinical Pharmacology·C FerrariM Romussi
Oct 1, 1984·Acta diabetologica latina·P MatsumotoJ C Dunbar
Jul 1, 1982·Acta diabetologica latina·A PezzarossaU Butturini
Jan 1, 1991·Life Sciences·K M Wozniak, M Linnoila
Sep 20, 1979·World Journal of Surgery·B M Jaffe
Mar 30, 2016·Pharmacology Research & Perspectives·Michael D NguyenB Jill Venton
Oct 6, 2017·Frontiers in Cellular Neuroscience·Steven C WylerChen Liu
Aug 3, 2020·Domestic Animal Endocrinology·S L FieldJ Laporta

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