Inhibition of glucagon secretion

Advances in Pharmacology
Andrew Young


This chapter describes a physiological and profound effect of amylin to inhibit meal-related glucagon secretion. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. In addition to amino acid nutrient stimuli, glucagon is also secreted in response to stressful stimuli, such as hypoglycemia and hypovolemia. Glucagon primarily acts on liver to initiate glycogenolysis and gluconeogenesis, resulting in a rapid increase in endogenous production of glucose. With longer stimulation, glucagon action at the liver results in a glucose-sparing activation of free fatty acid oxidation and production of ketones. During hypoglycemia, glucagon secretion is clearly a protective feed-back, defending the organism against damaging effects of low glucose in brain and nerves (neuroglycopenia). Amino acid-stimulated glucagon secretion during meals has a different purpose: amino acids stimulate insulin secretion, which mobilizes amino acid transporters and effects their storage in peripheral tissues. At the same time, insulin obligatorily recruits GLUT4 glucose transporters in muscle and fat. The hypoglycemic potential of such GLUT4 mobilization is averted only by the simultaneous liberation...Continue Reading


Nov 1, 1978·Metabolism: Clinical and Experimental·R H Unger
Nov 1, 1975·The Journal of Clinical Investigation·P RaskinR H Unger
Apr 1, 1990·The Journal of Clinical Investigation·G C Weir, S Bonner-Weir
Feb 13, 1986·Biochemical and Biophysical Research Communications·R A SilvestreJ Marco
Feb 1, 1986·Clinics in Endocrinology and Metabolism·E SamolsG C Weir
Oct 1, 1988·Regulatory Peptides·M Pettersson, B Ahrén
Aug 1, 1987·Diabetes·G M ArgoudR P Eaton
Oct 1, 1985·Diabetes Research and Clinical Practice·R KawamoriH Abe
Jul 16, 1970·The New England Journal of Medicine·W A MüllerR H Unger
Apr 1, 1970·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Dec 1, 1984·The Journal of Clinical Investigation·H MaruyamaR H Unger
Mar 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K InoueH Nawata
Jan 1, 1997·Metabolism: Clinical and Experimental·B R GedulinA A Young
Jan 1, 1997·Annual Review of Physiology·J J Holst
Nov 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·L OrskovO Schmitz
Jan 14, 2000·European Journal of Endocrinology·P R OskarssonU C Adamson
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M FinemanO G Kolterman

❮ Previous
Next ❯


Jun 4, 2010·European Heart Journal·Raffaele De CaterinaThomas Wascher
Jan 21, 2012·The Review of Diabetic Studies : RDS·Mikkel ChristensenFilip K Knop
Sep 13, 2011·Food & Nutrition Research·Katri PeuhkuriRiitta Korpela
Feb 5, 2011·Expert Opinion on Pharmacotherapy·Berhane Seyoum
Sep 17, 2009·Diabetes·Dale S EdgertonAlan D Cherrington
Jul 31, 2016·The Journal of Endocrinology·Petra KaválkováMartin Haluzík
Mar 19, 2014·Metabolism: Clinical and Experimental·Kristin M HirahatakeSean H Adams
Oct 21, 2017·Expert Opinion on Investigational Drugs·André J ScheenPierre J Lefèbvre
Oct 29, 2017·Current Diabetes Reports·Magnus F GrøndahlFilip K Knop
Oct 16, 2008·Medicinal Research Reviews·Michael L MohlerDuane D Miller
Aug 27, 2017·Diabetes, Obesity & Metabolism·Derek J Nunez, David D'Alessio
Jun 24, 2008·Expert Review of Cardiovascular Therapy·Stephen Fava
Jul 12, 2011·Physiological Reviews·Per WestermarkGunilla T Westermark
Jun 14, 2019·Chemical Society Reviews·Michael C OwenBirgit Strodel
Jan 8, 2013·ChemMedChem·Chandralal M Hewage, Kalyana C Venneti
Jun 14, 2015·Pharmacological Reviews·Debbie L HayJonathan D Roth
Feb 20, 2007·The Journal of Pharmacology and Experimental Therapeutics·Noelia RiveraAlan D Cherrington
Mar 29, 2019·Current Protein & Peptide Science·Wei LingHai-Lu Zhao
Mar 31, 2016·Diabetes, Obesity & Metabolism·J B HarpJ Gromada
May 12, 2017·Anais Da Academia Brasileira De Ciências·Luís M T R Lima
Jan 11, 2013·Journal of Diabetes·Yvan GosmainJacques Philippe
May 3, 2021·Physiology & Behavior·Miriam HoneggerChristina N Boyle

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.