Inhibition of glucose transporter 1 induces apoptosis and sensitizes multiple myeloma cells to conventional chemotherapeutic agents

Leukemia Research
Taichi MatsumotoShuuji Hara

Abstract

Despite the recent development of anti-myeloma drugs, the prognosis of high-risk multiple myeloma remains poor. Therefore, new effective treatment strategies for this disease are needed. It has been reported that high intensity of 18-fluorodeoxyglucose positron emission tomography is high-risk factor in myeloma, suggesting that glucose uptake can be therapeutic target in high-risk myeloma. In this study, we addressed the utility of glucose transporter 1 (GLUT1) as a therapeutic target for myeloma with increased glucose uptake. We found myeloma cell lines with elevated glucose uptake activity via GLUT1 up-regulation. STF-31, a selective GLUT1 inhibitor, completely suppressed the glucose uptake activity and induced apoptosis in GLUT1 expressing myeloma cells. On the other hand, this agent little shows the cytotoxicity in normal peripheral blood mononuclear cells. Moreover, STF-31 synergistically enhanced the cell death induced by melphalan, doxorubicin, and bortezomib. GLUT1 may be promising therapeutic target in myeloma with elevated glucose uptake.

References

Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Sep 5, 2002·Nature Reviews. Cancer·Sanjiv Sam Gambhir
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfredo BerrutiUNKNOWN Epirubicin-Lonidamine Group, Orbassano, Torino, Italy
Oct 25, 2003·Oncogene·Kathleen W Scotto
Jun 13, 2006·Cancer Cell·Thi Bui, Craig B Thompson
Aug 15, 2006·Cancer Chemotherapy and Pharmacology·Xianhua CaoDuxin Sun
Apr 29, 2008·Molecular Cell·Dana M GwinnReuben J Shaw
Aug 4, 2009·The Journal of Biological Chemistry·Mala ShanmugamSteven T Rosen
Mar 6, 2010·Cell Death and Differentiation·A Caro-MaldonadoC Muñoz-Pinedo
Dec 4, 2010·Science·Steven L McKnight
Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Apr 28, 2011·Nature Reviews. Clinical Oncology·S Vincent Rajkumar
Aug 5, 2011·Science Translational Medicine·Denise A ChanAmato J Giaccia
Jan 12, 2013·Virchows Archiv : an International Journal of Pathology·Pramila RamaniMargaret T May
Mar 20, 2013·Molecular Aspects of Medicine·Mike Mueckler, Bernard Thorens
Aug 8, 2014·Redox Biology·Stanley AndrisseJonathan S Fisher

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Citations

Oct 19, 2016·Scientific Reports·Nurbek MambetsarievGail A Bishop
Feb 22, 2017·Journal of Pathology and Translational Medicine·Young Wha KohJooryung Huh
Jul 1, 2017·Angewandte Chemie·Lucien N LameijerSylvestre Bonnet
Oct 24, 2017·Journal of Cellular Physiology·Mattia CriscuoliAntonella Naldini
Jun 28, 2018·Cellular Oncology (Dordrecht)·Dominik KrausRainer Probstmeier
Jun 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Qiuyan YanHongda Wang
Apr 18, 2018·International Journal of Molecular Sciences·Chaima El ArfaniEline Menu
Dec 23, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Di WuZhengkai Wei
May 4, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alecio F LombardiEric Y Chang
Jun 3, 2021·Cancers·Mélody CaillotBrigitte Sola
Dec 4, 2021·Frontiers in Cellular and Infection Microbiology·Kuerbannisha AmahongGuodong Lü

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Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis