Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic benefits

Parasitology Research
R Ahmad, Arvind K Srivastava

Abstract

The rapidly developing resistance to drugs used for prophylaxis and treatment of malaria makes the identification of novel drug targets necessary. Glutathione-S-transferase (GST, E.C. 2.5.1.18), an important enzyme of the glutathione (GSH) cycle, is considered to be an essential detoxification enzyme in malarial parasites. Selective inhibition of this enzyme from malarial parasites by various classes of inhibitors may be viewed as a potential chemotherapeutic strategy to combat malaria. Purified GST from Plasmodium yoelii was inhibited by compounds like protoporphyrin IX, cibacron blue, as well as by the GSH depletor menadione. Cytosolic GST was inhibited to varying degrees by each compound. A characteristic inhibitor constant (Ki) was obtained for each inhibitor. The possible consequences of selective inhibition of parasitic GST to that of the host are discussed in relation to the chemotherapy of malaria.

Citations

Jun 30, 2009·Parasitology Research·Lakshmy SrinivasanKalyanasundaram Muthuswamy
Jan 6, 2011·Parasitology Research·Lakshmy SrinivasanKalyanasundaram Muthuswamy
Feb 15, 2014·Parasitology Research·Murtala Bindawa Isah, Mohammed Auwal Ibrahim
Jul 24, 2008·Cellular Microbiology·Nathalie VonlaufenWilliam J Sullivan
May 4, 2017·The FEBS Journal·Reginald A KavisheMichael Alifrangis
Feb 28, 2020·The Journal of Antimicrobial Chemotherapy·Domingos Magno Santos PereiraElizabeth Soares Fernandes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.