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Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic benefits

Parasitology Research

Jan 9, 2008

Rumana Ahmad, Arvind K Srivastava

Abstract

The rapidly developing resistance to drugs used for prophylaxis and treatment of malaria makes the identification of novel drug targets necessary. Glutathione-S-transferase (GST, E.C. 2.5.1.18), an important enzyme of the glutathione (GSH) cycle, is considered to be an essential detoxif...read more

Mentioned in this Paper

Plasmodium yoelii
Metabolic Detoxication, Drug
Glutathione Measurement
Yb-Glutathione-S-Transferase
Malaria
Malaria Vaccines
Basilen Blue
Metabolic Inhibition
Benzotriazines
Protoporphyrin IX
Paper Details
References
  • References5
  • Citations6
1

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Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic benefits

Parasitology Research

Jan 9, 2008

Rumana Ahmad, Arvind K Srivastava

PMID: 18180958

DOI: 10.1007/s00436-007-0836-9

Abstract

The rapidly developing resistance to drugs used for prophylaxis and treatment of malaria makes the identification of novel drug targets necessary. Glutathione-S-transferase (GST, E.C. 2.5.1.18), an important enzyme of the glutathione (GSH) cycle, is considered to be an essential detoxif...read more

Mentioned in this Paper

Plasmodium yoelii
Metabolic Detoxication, Drug
Glutathione Measurement
Yb-Glutathione-S-Transferase
Malaria
Malaria Vaccines
Basilen Blue
Metabolic Inhibition
Benzotriazines
Protoporphyrin IX

Similar Papers Found In These Feeds

Plasmodium Falciparum

Malaria remains a major cause of morbidity and mortality in the tropics, with the parasite Plasmodium falciparum responsible for the majority of the disease burden. Discover the latest research on Plasmodium falciparum.

Malaria Vaccines

Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.

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Journal of Molecular Modeling

Structure of glutathione S-transferase of the filarial parasite Wuchereria bancrofti: a target for drug development against adult worm

Journal of Molecular ModelingMay 3, 2005
Sivaramakrishnan Thirumalai NathanKothandapani Balaraman
Paper Details
References
  • References5
  • Citations6
1
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