Jan 1, 1975

Inhibition of glycolysis in hearts during ischemic perfusion

Recent Advances in Studies on Cardiac Structure and Metabolism
J R NeelyM J Rovetto

Abstract

Rates of glycolysis were determined in the isolated perfused rat heart under aerobic, anoxic, and ischemic conditions. The rate was accelerated in anoxic and was inhibited in ischemic tissue. Glycolytic inhibition developed at the level of glyceraldehyde-3-P dehydrogenase and was associated with accumulation of high levels of tissue lactate and H+.

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Mentioned in this Paper

Lactate
Perfusion
Myocardium
Lactic Acid Measurement
Glyceraldehyde
Lactates
Anoxemia
Anaerobiosis
Glycolysis Inhibition
Metabolic Inhibition

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