Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene

World Journal of Gastroenterology : WJG
Xiao-guang LuJi-Hong Xie

Abstract

To investigate the effects and mechanism of d-limonene on the growth and metastasis of gastric cancer in vivo. Metastatic model simulating human gastric cancer was established by orthotopic implantation of histologically intact human tumor tissue into gastric wall of nude mice. One percent d-limonene was orally administered at dose of 15 ml/kg every other day for seven weeks. Eight weeks after implantation, tumor weight, inhibition rate, apoptotic index (AI), microvessel density (MVD), vascular endothelial growth factor (VEGF), variation of ultrastructure, and the presence of metastasis were evaluated, respectively, after the mice were sacrificed. The tumor weight was significantly reduced in 5-FU group (2.55+/-0.28 g), d-limonene group (1.49+/-0.09 g) and combined treatment group (1.48+/-0.21 g) compared with the control group(2.73+/-0.23 g, P<0.05). In 5-FU group, d-limonene group, combined treatment group, the inhibition rates were 2.60%,47.58% and 46.84% and 0, respectively; AI was (3.31+/-0.33)%, (8.26+/-1.21)%, (20.99+/-1.84)% and (19.34+/-2.19)%, respectively; MVD was (8.64+/-2.81), (16.77+/-1.39), (5.32+/-4.26) and (5.86+/-2.27), respectively; VEGF expression was (45.77+/-4.79), (41.34+/-5.41), (29.71+/-8.92) and (28.24...Continue Reading

References

Jan 1, 1995·Breast Cancer Research and Treatment·J Folkman
Jun 1, 1996·Cancer Metastasis Reviews·W Risau
Jan 1, 1996·Advances in Experimental Medicine and Biology·S A BroitmanS K Branch
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S P StrattonD S Alberts
Jul 4, 2001·International Journal of Cancer. Journal International Du Cancer·I KajiH Kasugai
Aug 14, 2002·World Journal of Gastroenterology : WJG·Juan RenBo-Rong Pan
Oct 2, 2002·Current Oncology Reports·Kathryn Z Guyton, Thomas W Kensler
Nov 27, 2002·Clinical Colorectal Cancer·Michal G RoseJohn C Schmitz

❮ Previous
Next ❯

Citations

Mar 27, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Denise C ArrudaSilvia R B Uliana
Jun 24, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jessica A MillerH-H Sherry Chow
May 17, 2014·Phytotherapy Research : PTR·Jean-François LesgardsSylvia Pietri
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mounira KrifaLeila Chekir-Ghedira
Jun 26, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Franco Matías EscobarLiliana Inés Sabini
Dec 17, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sarah AfshordelGunter P Eckert
Oct 27, 2015·Plant Biology·M T WellingK Benkendorff
Oct 25, 2008·Chemical Society Reviews·Min-Hsiung Pan, Chi-Tang Ho
Apr 27, 2017·Toxicological Research·Kyoung Sang ChoIm-Soon Lee
May 30, 2013·Human & Experimental Toxicology·S Kapoor
Aug 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandro BurianiMaria Carrara
Jun 29, 2011·Journal of Toxicology and Environmental Health. Part a·Zahira Fernández-BedmarJoaquín Pérez-Guisado
Sep 16, 2017·Journal of Complementary & Integrative Medicine·Wissem Aidi WannesBrahim Marzouk
Sep 23, 2011·Pharmaceutical Biology·Girija KuttanRamadasan Kuttan
Nov 22, 2012·Experimental and Therapeutic Medicine·Zhen-Hai MaYong-Fu Zhao
Jun 26, 2017·Asian Pacific Journal of Tropical Medicine·Filippo GiarratanaAntonio Panebianco
Oct 19, 2019·Scientific Reports·Carolina V PereiraAna Matias
Sep 26, 2020·Journal of Fungi·Julián E MuñozCarlos Pelleschi Taborda
Feb 10, 2012·Human & Experimental Toxicology·S C ChaudharyM Sarwar Alam
Dec 9, 2020·Journal of Food Biochemistry·Pandi AnandakumarManickam Kalappan Vanitha
Apr 18, 2021·Phytotherapy Research : PTR·Heitor Gomes de Araújo-FilhoJullyana S S Quintans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.