Abstract
To investigate the effects and mechanism of d-limonene on the growth and metastasis of gastric cancer in vivo. Metastatic model simulating human gastric cancer was established by orthotopic implantation of histologically intact human tumor tissue into gastric wall of nude mice. One percent d-limonene was orally administered at dose of 15 ml/kg every other day for seven weeks. Eight weeks after implantation, tumor weight, inhibition rate, apoptotic index (AI), microvessel density (MVD), vascular endothelial growth factor (VEGF), variation of ultrastructure, and the presence of metastasis were evaluated, respectively, after the mice were sacrificed. The tumor weight was significantly reduced in 5-FU group (2.55+/-0.28 g), d-limonene group (1.49+/-0.09 g) and combined treatment group (1.48+/-0.21 g) compared with the control group(2.73+/-0.23 g, P<0.05). In 5-FU group, d-limonene group, combined treatment group, the inhibition rates were 2.60%,47.58% and 46.84% and 0, respectively; AI was (3.31+/-0.33)%, (8.26+/-1.21)%, (20.99+/-1.84)% and (19.34+/-2.19)%, respectively; MVD was (8.64+/-2.81), (16.77+/-1.39), (5.32+/-4.26) and (5.86+/-2.27), respectively; VEGF expression was (45.77+/-4.79), (41.34+/-5.41), (29.71+/-8.92) and (28.24...Continue Reading
References
Jan 1, 1995·Breast Cancer Research and Treatment·J Folkman
Jun 1, 1996·Cancer Metastasis Reviews·W Risau
Jan 1, 1996·Advances in Experimental Medicine and Biology·S A BroitmanS K Branch
Jul 15, 1997·Cancer Letters·A NakaizumiM Tatsuta
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O N El-AssalN Nagasue
Jun 22, 1999·Cancer Letters·N UedoT Otani
Apr 28, 2000·Carcinogenesis·H WitschiI Espiritu
May 23, 2000·Cancer·Y SeoK Sugimachi
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S P StrattonD S Alberts
Jul 4, 2001·International Journal of Cancer. Journal International Du Cancer·I KajiH Kasugai
Aug 14, 2002·World Journal of Gastroenterology : WJG·Juan RenBo-Rong Pan
Oct 2, 2002·Current Oncology Reports·Kathryn Z Guyton, Thomas W Kensler
Nov 27, 2002·Clinical Colorectal Cancer·Michal G RoseJohn C Schmitz
Jul 11, 2003·World Journal of Gastroenterology : WJG·Hai ShiHui-Jun Xie
Citations
Oct 20, 2015·Journal of Cellular Biochemistry·Mounira KrifaPhilippe Rondé
Mar 27, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Denise C ArrudaSilvia R B Uliana
Jun 24, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jessica A MillerH-H Sherry Chow
Jan 3, 2007·Phytotherapy Research : PTR·Amr E Edris
May 17, 2014·Phytotherapy Research : PTR·Jean-François LesgardsSylvia Pietri
Dec 19, 2015·Oxidative Medicine and Cellular Longevity·Jie BaiPing Liu
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mounira KrifaLeila Chekir-Ghedira
Jun 26, 2015·Pharmacognosy Magazine·I E CockB Matthews
Jun 26, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Franco Matías EscobarLiliana Inés Sabini
Dec 17, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sarah AfshordelGunter P Eckert
Sep 1, 2012·Life Sciences·Kotamballi N Chidambara MurthyBhimanagouda S Patil
Oct 27, 2015·Plant Biology·M T WellingK Benkendorff
Aug 24, 2016·International Journal of Food Microbiology·Filippo GiarratanaAntonio Panebianco
Oct 25, 2008·Chemical Society Reviews·Min-Hsiung Pan, Chi-Tang Ho
Apr 27, 2017·Toxicological Research·Kyoung Sang ChoIm-Soon Lee
Mar 24, 2010·Integrative Cancer Therapies·Peng WangLu-Ming Liu
May 30, 2013·Human & Experimental Toxicology·S Kapoor
Aug 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandro BurianiMaria Carrara
Aug 15, 2009·Cancer Chemotherapy and Pharmacology·S J GreayC F Carson
Jun 29, 2011·Journal of Toxicology and Environmental Health. Part a·Zahira Fernández-BedmarJoaquín Pérez-Guisado
Apr 24, 2014·Indian Journal of Clinical Biochemistry : IJCB·Regi JoseK T Augusti
Sep 16, 2017·Journal of Complementary & Integrative Medicine·Wissem Aidi WannesBrahim Marzouk
Sep 23, 2011·Pharmaceutical Biology·Girija KuttanRamadasan Kuttan
Nov 22, 2012·Experimental and Therapeutic Medicine·Zhen-Hai MaYong-Fu Zhao
Aug 2, 2016·Biological & Pharmaceutical Bulletin·JingZhe LiTakashi Sato
Jun 26, 2017·Asian Pacific Journal of Tropical Medicine·Filippo GiarratanaAntonio Panebianco
Feb 6, 2018·Experimental and Therapeutic Medicine·Xifeng WangWei Shen
Nov 18, 2018·Inflammopharmacology·Elsayed OmerIan E Cock
Mar 21, 2019·Animal Models and Experimental Medicine·Bhavini B ShahAnita A Mehta
Oct 19, 2019·Scientific Reports·Carolina V PereiraAna Matias
Sep 26, 2020·Journal of Fungi·Julián E MuñozCarlos Pelleschi Taborda
Nov 3, 2012·Oncology Reports·Shu-Sheng JiaYan-Mei Yang
Apr 1, 2019·Veterinary World·Mohammad H GharaibehLuay F Abu-Qatouseh
Feb 10, 2012·Human & Experimental Toxicology·S C ChaudharyM Sarwar Alam
Jul 28, 2010·Nutrition and Cancer·Jessica A MillerH-H Sherry Chow
Jul 28, 2020·Cancers·Andrea M TomkoDenis J Dupré
Jan 30, 2021·Oxidative Medicine and Cellular Longevity·Esmaeel BabaeenezhadHassan Ahmadvand
Dec 9, 2020·Journal of Food Biochemistry·Pandi AnandakumarManickam Kalappan Vanitha
Apr 18, 2021·Phytotherapy Research : PTR·Heitor Gomes de Araújo-FilhoJullyana S S Quintans
Jun 24, 2021·Food & Function·Tengteng ZhuBiyun Qian