Inhibition of growth hormone secretion in mild primary hyperparathyroidism

Hormone Research
Vittorio CoiroGloria Saccani Jotti

Abstract

Impairment in growth hormone (GH) secretion has been reported to occur in primary hyperparathyroidism (PHP) with strikingly elevated (>150 pg/ml) plasma PTH and free Ca levels. Patients with these characteristics are relatively few, whereas the great majority of patients with biochemically diagnosed PHP are asymptomatic and show borderline or slightly elevated plasma PTH and Ca levels. We wondered whether also patients in these latter conditions show a defective GH secretory pattern. In order to answer this question, 8 female subjects (mean age +/- SE: 44 +/- 1.3 years) were selected at the time of a checkup examination from a larger population of persons in fairly good clinical condition. Inclusion criteria were plasma PTH values slightly above the normal range (up to 50% higher than the maximum limit) with free Ca levels in the upper normal range or slightly higher (experimental group). Normal values in our laboratory are ionized calcium: 1.22-1.42 mmol/ml and plasma PTH: 12-72 pg/ml. A group of 15 age-matched healthy women with plasma PTH and Ca levels in the middle normal range and significantly lower than values found in the experimental group was also selected and used as control. Experimental and control groups were test...Continue Reading

References

Oct 21, 1999·The New England Journal of Medicine·S J SilverbergJ P Bilezikian
Oct 21, 1999·The New England Journal of Medicine·R D Utiger
Jul 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M InabaY Nishizawa
Aug 29, 2000·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·C HasseM Rothmund
Dec 7, 2000·Journal of Clinical Epidemiology·R JordeJ Sundsfjord

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Citations

Jul 3, 2021·Cells·Marina CaputoFlavia Prodam

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