PMID: 6162552Mar 1, 1980Paper

Inhibition of growth of B16 murine malignant melanoma by exogenous interferon

Cancer Research
R S BartY Farcet

Abstract

We previously reported that polyinosinic-polycytidylic acid, a potent interferon inducer, inhibits the growth of B16 malignant melanoma in the C57BL/6 mouse. Two experiments were done to evaluate the effectiveness of interferon in tumor inhibition in vivo. In the first, mice were implanted with melanoma and divided into four groups, according to treatment: interferon preparation; interferon control preparation ("breakthrough fraction"); phosphate-buffered saline control; and murine serum albumin control. Daily, each mouse was given i.p. injections of 200,000 NIH reference units (hereafter called units) of interferon or of one of the control substances. The second experiment was similar to the first, except that bovine serum albumin was an additional control. In both experiments, the average tumor volume in interferon-treated mice was statistically significantly smaller than that of each control group. Mouse interferon preparations also inhibited the multiplication of B16 malignant melanoma cells in culture. This inhibition was statistically significant from interferon levels as low as 5 to as high as 5000 units/ml. The degree of inhibition markedly increased from 5 up to 500 units, the inhibition reaching its maximum at this co...Continue Reading

Citations

Mar 14, 2003·Critical Reviews in Oncology/hematology·Timothy M Pawlik, Vernon K Sondak
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·H M HortonS E Parker
Aug 3, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sherrif F IbrahimDésirée Ratner
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Apr 1, 1983·[Rinshō ketsueki] The Japanese journal of clinical hematology·Y KonakaS Konda
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Jun 28, 2014·Oncology Reports·Sadek MalasSophia N Karagiannis

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