Inhibition of head and neck tumor cell growth with arachidonic acid metabolism inhibition

The Laryngoscope
Frank G OndreyG L Adams

Abstract

Head and neck tumors are known to synthesize arachidonic acid metabolites. The authors have postulated that these substances may confer growth advantage to cancer cells, and by interfering with arachidonic acid metabolism squamous cancer growth may be altered. The tongue derived squamous carcinoma cell line, SCC-25, was treated with three leukotriene synthesis inhibitors and indomethacin. A dose-dependent decrease in DNA synthesis occurred with leukotriene inhibition, but not prostaglandin inhibition. All leukotriene synthesis inhibitors produced a dramatic and immediate effect ( > 70% inhibition by 4 hours) without cytotoxicity ( > 90% trypan blue exclusion). Cell populations at 96 hours were decreased when compared to control populations. In conclusion, leukotrienes or other lipoxygenase products may play a role as growth factors for squamous cell carcinoma, and arachidonic acid inhibition may be a novel target for chemotherapeutic intervention.

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·I KlapanV Cuk
Jun 1, 1990·The British Journal of Oral & Maxillofacial Surgery·I E el-HakimJ F Costello
Jan 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S PintoR Abbate
Mar 1, 1990·American Journal of Otolaryngology·Z CenikY Uyar
Oct 1, 1989·Journal of Neurosurgery·D E WilsonJ E Harris
Jul 1, 1985·The Journal of Clinical Investigation·L BaudR Ardaillou
Jan 1, 1986·The Journal of Clinical Investigation·A P Pentland, P Needleman
Mar 15, 1984·European Journal of Biochemistry·H KühnS M Rapoport
Jun 12, 1981·Science·K V HonnA Skoff
Feb 2, 1994·Journal of the National Cancer Institute·K Smigel

❮ Previous
Next ❯

Citations

Mar 17, 2011·Cancer Causes & Control : CCC·Jessica C WilsonCarmel M Hughes
Jun 1, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Laura MasiAlessandro Franchi
Jul 16, 2010·International Journal of Otolaryngology·Neda AhmadiBruce J Davidson
Apr 29, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A PrzylipiakF M Köhn
Jul 27, 2010·Prostaglandins & Other Lipid Mediators·Sittichai KoontongkaewTheeranuch Saensuk
Jan 10, 2008·International Journal of Cancer. Journal International Du Cancer·Sebastian GlattWolfgang Sommergruber
May 15, 2015·International Journal of Cancer. Journal International Du Cancer·Claudia BeckerChristoph R Meier
Jan 29, 2014·Oral Oncology·Sachin C SarodeAnuprita Patil
Dec 15, 2010·Journal of the Korean Society of Coloproctology·Yoon Dae HanChan Heun Park
Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·D G TangA T Porter
Jul 14, 2018·International Journal of Molecular Sciences·Xiaoqi ZhangMinqi Li
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ning LiXiaoxin Chen
Sep 4, 2015·The Journal of Contemporary Dental Practice·Gargi S SarodeDominic Augustine
Apr 28, 2001·Neoplasia : an International Journal for Oncology Research·O GalloE Masini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
K SumitaniMasao Nagumo
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Vassiliki A PapadimitrakopoulouJay O Boyle
© 2021 Meta ULC. All rights reserved