PMID: 11929405Apr 4, 2002Paper

Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils

Alimentary Pharmacology & Therapeutics
S FutagamiM Kobayashi

Abstract

The effect of Helicobacter pylori infection on non-steroidal anti-inflammatory drug-induced gastric mucosal injury is controversial. To examine the effect of the interaction between H. pylori and non-steroidal anti-inflammatory drugs on gastric mucosal injury. Mongolian gerbils infected with H. pylori were treated with indometacin at 8 mg/kg for 2 days or 7 days. Mucosal damage was assessed by macroscopic and histological examination, and myeloperoxidase activity was measured as an index of neutrophil infiltration. The expression levels of cyclo-oxygenase proteins were determined by Western blot analysis and cyclo-oxygenase activity. A 2-day course of indometacin did not cause an increase in gastric damage in H. pylori-infected Mongolian gerbils compared to uninfected gerbils, while a 7-day course of indometacin caused additive gastric damage in H. pylori-infected animals. H. pylori infection induced cyclo-oxygenase-2 expression in the stomach. Treatment with indometacin for 2 days did not significantly affect cyclo-oxygenase activity in H. pylori-infected animals, while treatment for 7 days inhibited both cyclo-oxygenase-1 and cyclo-oxygenase-2 activities. Pre-treatment with a selective cyclo-oxygenase-2 inhibitor aggravated m...Continue Reading

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Citations

Aug 24, 2005·Médecine sciences : M/S·Marie-Thérèse Bluet-PajotJacques Epelbaum
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Larry H Lai, Joseph J Y Sung
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Mar 24, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Francis K L Chan
Sep 6, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tetsuya TanigawaTetsuo Arakawa
Nov 18, 2003·Helicobacter·Dominique Lamarque, Richard M Peek

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