Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin

Apoptosis : an International Journal on Programmed Cell Death
Xin LvBao-shan Wang

Abstract

It has been previously reported that cisplatin is a well-known anticancer drug being used against a wide range of malignancies including head and neck, ovarian and non-small cell lung carcinoma, and demonstrated its anticancer activity by reacting with DNA or changing cell structure, immune response, reactive oxygen species level (ROS). In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation. The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin. Furthermore, the HO-1 expression induced by cisplatin was strongly inhibited by the knockdown of nuclear factor-erythroid-2-related factor-2 (Nrf-2), and the oxidative damages induced by cisplatin were significantly enhanced. Therefore, it may be concluded that the inhibition of HO-1 or the knockdown of Nrf-2 significantly enhanced cisplatin's anticancer effects on Hep-2 cells. In clinic, with the overexpression of HO-1 in laryngeal squamous cancer tissues, the combination of cisplatin with the inhibitor of HO-1 or Nrf-2 siRNA may act...Continue Reading

References

Jan 22, 2003·Virchows Archiv : an International Journal of Pathology·Alfons Nadal, Antonio Cardesa
Jan 24, 2004·Apoptosis : an International Journal on Programmed Cell Death·J FangH Maeda
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Jong-Min Lee, Jeffrey A Johnson
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pascal O BerberatHelmut Friess
Nov 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ricardo HittHernán Cortés-Funes
Feb 27, 2007·Free Radical Biology & Medicine·Christine MarzanoMaria Pia Rigobello
May 17, 2007·Apoptosis : an International Journal on Programmed Cell Death·Paloma BragadoAlmudena Porras
Sep 8, 2007·Antioxidants & Redox Signaling·Alicja JozkowiczJozef Dulak
Nov 17, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hak-Ryul KimRaekil Park
Nov 13, 2008·Apoptosis : an International Journal on Programmed Cell Death·Ruifen ZhangSanjay K Srivastava
Nov 3, 2009·Apoptosis : an International Journal on Programmed Cell Death·Nahed El-NajjarHala Gali-Muhtasib
Feb 4, 2010·Apoptosis : an International Journal on Programmed Cell Death·Varisa PongrakhananonPithi Chanvorachote
Mar 24, 2010·Free Radical Biology & Medicine·Sang Eun KimKeon Wook Kang
Aug 14, 2010·Current Drug Targets·Halina WasAlicja Jozkowicz
Nov 18, 2010·Apoptosis : an International Journal on Programmed Cell Death·Jayaraj RavindranP V Lakshmana Rao
Feb 18, 2011·Journal of Neuro-oncology·Yaohua LiuShiguang Zhao
Jun 22, 2011·Biochemical and Biophysical Research Communications·Hai-Yan XingPei-Yuan Xia
Oct 25, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yoon-Jin LeeSang-Han Lee
Dec 7, 2011·Free Radical Biology & Medicine·Anna Lisa FurfaroNicola Traverso
Apr 10, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K J Senthil KumarSheng-Yang Wang
Jul 10, 2012·American Journal of Otolaryngology·Rong KangShu-Xin Wen
Feb 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Jing WangXuebo Liu
Nov 5, 2013·Antioxidants & Redox Signaling·Louise L DunnRoland Stocker
Nov 10, 2013·Free Radical Biology & Medicine·Hye-Kyung Na, Young-Joon Surh
Nov 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Norberto A GandiniAlejandro C Curino
Jan 18, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yasin TayemRoberta Foresti
Mar 22, 2014·Cell Death & Disease·B WegielL E Otterbein
Apr 25, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lakshmi Narendra BodduluruRamakrishna Sistla
Apr 30, 2014·Cancer Immunology Research·James N ArnoldDouglas T Fearon
Jul 25, 2014·European Journal of Pharmacology·Shaloam Dasari, Paul Bernard Tchounwou
Apr 18, 2015·Journal of Biomedical Science·Lee-Young Chau
Apr 22, 2015·Cancer Chemotherapy and Pharmacology·Jianli ChenHenry Simpkins

❮ Previous
Next ❯

Citations

May 6, 2017·Antioxidants·Mariapaola NittiAnna Lisa Furfaro
May 14, 2019·Journal of Cellular Biochemistry·Yuyan WuJing Wang
Oct 17, 2019·Antioxidants·J Catharina DuvigneauAndrey V Kozlov
Nov 11, 2019·Breast Cancer Research and Treatment·Natasha TraceyValerie G Brunton
Jul 7, 2020·International Journal of Oncology·Fatima MohammedSalim Fredericks
Dec 26, 2018·International Journal of Molecular Sciences·Shih-Kai ChiangLing-Chu Chang
Feb 29, 2020·Molecular Neurobiology·Carlo Castruccio CastracaniGiovanni Li Volti
May 18, 2019·Oxidative Medicine and Cellular Longevity·Emiliano Panieri, Luciano Saso
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe RomeoLoredana Salerno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.