Inhibition of hepatitis B virus deoxyribonucleic acid polymerase by the 5'-triphosphates of 9-beta-D-arabinofuranosyladenine and 1-beta-D-arabinofuranosylcytosine.

Antimicrobial Agents and Chemotherapy
G HessK H Meyer zum Büschenfelde

Abstract

9-beta-D-Arabinofuranosyladenine (ara-A), 1-beta-D-arabinofuranosylcytosine (ara-C), and their 5'-triphosphates (ara-ATP and ara-CTP) were tested for ability to inhibit the hepatitis B virus (HBV)-associated deoxyribonucleic acid (DNA) polymerase. Ara-C did not inhibit the HBV DNA polymerase at the concentrations tested, ara-A did so by 50% at a concentration of 30 mM, with the inhibition noncompetitive with respect to deoxyadenosine 5-triphosphate (dATP). Ara-ATP and ara-CTP inhibited the DNA polymerase test competitively with respect to dATP and dCTP, respectively. Both compounds were also active after initiation of the DNA polymerase reaction. The inhibition caused by ara-ATP and ara-CTP was shown to be reversible, with no evidence that ara-ATP or ara-CTP was incorporated into the HBV DNA.

References

Jun 1, 1976·The Journal of Infectious Diseases·A H RossC Balakrishnan
Mar 4, 1977·Annals of the New York Academy of Sciences·W E MüllerD Falke
Jan 1, 1977·Annual Review of Biochemistry·A Weissbach
Apr 21, 1978·JAMA : the Journal of the American Medical Association·R B PollardW S Robinson
Aug 19, 1978·British Medical Journal·R G ChadwickS Sherlock
Jan 1, 1977·Journal of Virology·L I Lutwick, W S Robinson
Mar 1, 1976·Journal of Virology·P M KaplanJ L Gerin
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W PlunkettS S Cohen
Nov 1, 1973·Journal of Virology·P M KaplanW S Robinson
Aug 1, 1974·Journal of Virology·W S RobinsonR L Greenman
Jan 1, 1966·Progress in Nucleic Acid Research and Molecular Biology·S S Cohen
Jan 1, 1965·Canadian Journal of Biochemistry·J J BRINK, G A LEPAGE

❮ Previous
Next ❯

Citations

Jan 1, 1990·Pharmacology & Therapeutics·G E Wright, N C Brown
Dec 1, 1986·Journal of Clinical and Hospital Pharmacy·S Dover

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.