PMID: 9525579Apr 3, 1998Paper

Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice

Journal of Virology
V J CavanaughF V Chisari

Abstract

We have previously demonstrated that hepatitis B virus (HBV) replication and gene expression are abolished in the livers of HBV transgenic mice by cytotoxic T lymphocytes (CTLs) and during lymphocytic choriomeningitis virus (LCMV) infection, stimuli that trigger the production of alpha/beta interferon, gamma interferon, and tumor necrosis factor alpha in the liver. We now report that hepatic HBV replication and gene expression are inhibited by the local induction of these cytokines during adenovirus- and murine cytomegalovirus (MCMV)-induced hepatitis. Further, we show that MCMV also blocks HBV replication and gene expression in the proximal convoluted tubules of the kidney by causing interstitial nephritis and inducing the same cytokines in the renal parenchyma. These results suggest that inflammatory cytokines probably contribute to viral clearance during acute viral hepatitis in humans, and they imply that induction of these cytokines in the liver and other infected tissues of chronically infected patients might have therapeutic value.

Citations

May 20, 1999·The Journal of Experimental Medicine·L G GuidottiF V Chisari
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Feb 1, 2002·The New England Journal of Medicine·Donald E Mosier, Francis V Chisari
Mar 9, 2002·Journal of Virology·Michael D RobekFrancis V Chisari
Oct 9, 2002·Journal of Virology·Kiminori KimuraFrancis V Chisari
May 14, 2005·Journal of Virology·Masanori IsogawaFrancis V Chisari
Nov 14, 2006·European Journal of Gastroenterology & Hepatology·Lan LinJohan Fevery
Dec 24, 2010·Journal of Gastroenterology and Hepatology·Noha G Bader el-DinMostafa K el-Awady
Nov 15, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yutaka HoriuchiToshitaka Akatsuka
Jul 19, 2000·The Journal of Experimental Medicine·H McClaryL G Guidotti
Oct 4, 2000·The Journal of Experimental Medicine·K KakimiF V Chisari
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R SchirmbeckJ Reimann
Feb 28, 2002·Journal of Virology·Luca G GuidottiFrancis V Chisari
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiminori KimuraFrancis V Chisari
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D RobekFrancis V Chisari
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Apr 10, 2013·International Journal of Immunogenetics·I KimkongN Hirankarn
Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jesse SummersWilliam S Mason
Jan 6, 2006·European Journal of Gastroenterology & Hepatology·Jürgen SieblerMarkus F Neurath
Mar 1, 2002·Immunology and Cell Biology·George Jm Webster, Antonio Bertoletti
Dec 18, 2007·Infection·K DeterdingH Wedemeyer
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Matteo IannaconeLuca G Guidotti
Jan 31, 2002·World Journal of Gastroenterology : WJG·X S ChenY P Hu
Apr 7, 2010·Journal of Viral Hepatitis·M John von FreyendU Protzer
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra PhillipsNikolai V Naoumov
Jun 3, 2000·Annual Review of Immunology·J T HartyD W White
Aug 22, 2000·The Journal of Experimental Medicine·V PasquettoF V Chisari
Jul 15, 2005·Journal of Virology·Stefan F Wieland, Francis V Chisari
Jul 18, 2001·The Journal of General Virology·D J TophamP C Doherty

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