Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative

FEBS Letters
Kevin J SalibaKiaran Kirk

Abstract

An O-3-hexose derivative, shown previously to inhibit a malaria parasite hexose transporter expressed in Xenopus oocytes as well as to suppress the multiplication of parasites, both in vitro and in vivo, was shown here to block the uptake of hexose sugars into isolated blood-stage parasites. This led to a decline in ATP levels and the loss of intracellular pH control. The results are consistent with those obtained with the cloned transporter. They support the notion that the transporter mediates uptake of glucose into the intraerythrocytic parasite and provide further support for the view that it is a suitable antimalarial drug target.

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Citations

Jun 1, 2005·Trends in Parasitology·Giancarlo A BiaginiPatrick G Bray
Oct 11, 2011·The Journal of Biological Chemistry·Praveen Balabaskaran NinaAkhil B Vaidya
May 30, 2013·Antimicrobial Agents and Chemotherapy·Michael T HarrisJames C Morris
Mar 29, 2013·PloS One·Donelly A van SchalkwykKiaran Kirk
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May 29, 2012·IUBMB Life·Janina PreussKatja Becker
Nov 4, 2004·Trends in Parasitology·Katja Becker, Kiaran Kirk
Dec 12, 2013·The Biochemical Journal·Kiaran Kirk, Adele M Lehane
Nov 19, 2014·Bioscience Reports·Rongwei TengKiaran Kirk
Jun 26, 2007·Bioorganic & Medicinal Chemistry Letters·Marina IonitaAsha Parbhu Patel
Aug 8, 2015·Antimicrobial Agents and Chemotherapy·Thomas E KraftPaul W Hruz
Mar 2, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jelena KonstantinovićBogdan Šolaja
Aug 21, 2008·The Journal of Pharmacology and Experimental Therapeutics·Donelly A van SchalkwykKevin J Saliba
Nov 9, 2019·Biological Reviews of the Cambridge Philosophical Society·Rowena E Martin
Dec 12, 2020·Saudi Journal of Biological Sciences·Jesudass Joseph SahayarayanAbubaker M A Morgan

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