Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin

European Journal of Pharmacology
J P WangS C Kuo

Abstract

Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice. Liver glycogen content was increased in adrenalectomized mice pretreated with dexamethasone, but not with acetylshikonin. Like diphenhydramine, methysergide and isoproterenol, acetylshikonin reduced the plasma exudation evoked in dorsal hind-paw skin by antidromic stimulation of the saphenous nerve, and in passive cutaneous anaphylactic reaction, bradykinin-, substance P-, compound 48/80-, histamine- and serotonin-induced ear edema. Indomethacin was ineffective in these respects. Bradykinin- and substance P-induced plasma exudation were also significantly reduced when [Thi5,8,D-Phe7]bradykinin and [D-Pro2,D-Trp7,9]substance P were coinjected with bradykinin and substance P, respectively. In isolated rat peritoneal mast cell preparation, acetylshikonin produced a concentration-dependent inhibition of histamine and beta-glucuronidase release from mast cells challenged by compound 48/80. In compound 48/80-pretreated mice, acetylshikonin and isoproterenol produced significantly more inhibitory effect on bradykinin- and substance P-induc...Continue Reading

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Citations

Aug 8, 2002·Phytotherapy Research : PTR·Xin ChenM Zack Howard
Apr 25, 1997·Biochemical Pharmacology·J P Wang, S C Kuo
Oct 28, 1999·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·F WeiK Ren
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ting LiLiang Liu
Jul 18, 2009·Phytotherapy Research : PTR·Haeyong LeeYoosik Yoon
Sep 22, 2020·Pharmaceutical Biology·Zhiqin ZhangJian Ni

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