Inhibition of histamine release from human lung in vitro by antihistamines and related drugs

British Journal of Pharmacology
M K Church, C F Gradidge

Abstract

1 A series of cationic, lipophilic histamine H1-receptor antagonists, neuroleptics, antidepressants and monoamine oxidase inhibitors were tested for their effects on anti-IgE-induced histamine release from human lung fragments in vitro. 2 They had a biphasic effect: at low concentrations a dose-related inhibition of histamine release was observed whereas, at higher concentrations, the drugs liberated histamine even in the absence of antigen. 3 Mepyramine, a much less lipophilic drug than the others tested, was only weakly active on mast cells at pharmacological concentrations. 4 The potency of the drugs as release inhibitors was not related quantitatively to their histamine liberating potency. 5 There was no; correlation between activity on mast cells and histamine H1-receptor antagonism. 6 Mast cell stabilization may play a part in the activity of these drugs as anti-allergic agents.

References

Jan 1, 1977·The Journal of Allergy and Clinical Immunology·V T Popa
Jan 1, 1977·Respiration; International Review of Thoracic Diseases·J Zieliński, E Chodosowska
Jan 1, 1978·The Journal of International Medical Research·P Göbel
Jan 1, 1978·International Archives of Allergy and Applied Immunology·M BorgersP A Janssen
Jul 15, 1979·Biochemical Pharmacology·E K RooneyA G Lee
Aug 1, 1976·Biochemical Pharmacology·W KazimierczakC Maśliński
Jan 15, 1978·Biochemical Pharmacology·W KazimierczakC Maśliński
Feb 1, 1977·Acta Allergologica·J P Girard, M Cuevas
Dec 1, 1978·Agents and Actions·F De ClerckF Awouters
Nov 1, 1971·Acta Physiologica Scandinavica·M Frisk-Holmberg
May 1, 1972·European Journal of Pharmacology·M Frisk-Holmberg, E van der Kleijn
Aug 1, 1972·The Journal of Physiology·J C Foreman, J L Mongar
Apr 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·D P EvansD S Thomson
Jun 1, 1972·Experimental Cell Research·G Poste, P Reeve
Jul 3, 1971·The Medical Journal of Australia·R A MearesM J Rand
Sep 1, 1953·Japanese Journal of Pharmacology·H MAYEDA
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Sep 1, 1960·British Journal of Pharmacology and Chemotherapy·I MOTA, W da SILVA

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·J W PatersonR A Tarala
Apr 1, 1982·Agents and Actions·A TrunehF L Pearce
Sep 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M PerzanowskaM K Church
May 21, 1982·European Journal of Pharmacology·A J LewisM E Rosenthale
Jan 1, 1982·Pharmacology & Therapeutics·R J Davies, I Moodley
Mar 14, 2003·International Journal of Pediatric Otorhinolaryngology·David P McCormickTasnee Chonmaitree
Apr 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I M GarreldsF J Zijlstra
Oct 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K DobashiT Nakazawa
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M K Church
May 16, 2006·Treatments in Respiratory Medicine·Andrew M Wilson
Jul 1, 1991·Journal of the American Academy of Dermatology·C D Kennard, C N Ellis
Jul 15, 2015·Brain, Behavior, and Immunity·Lawrence B AfrinGerhard J Molderings
Jan 1, 1984·Toxicology and Applied Pharmacology·A J Januszkiewicz, M D Faiman
Jan 1, 1981·British Journal of Diseases of the Chest·T C Stokes, J Morley
Aug 1, 1989·The Journal of Allergy and Clinical Immunology·P Rafferty, S T Holgate
May 2, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Gerhard J MolderingsLawrence B Afrin
Feb 28, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M TriggianiG Marone
Oct 10, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J T SchroederW Kreutner
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R LeursM Taglialatela
Oct 10, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M K Church
Aug 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J Rimmer, M K Church
Aug 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P H Howarth
Jul 1, 1987·Clinical Allergy·R FadelE Henocq
Mar 26, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G MaroneM Triggiani
Feb 1, 1986·Postgraduate Medicine·D E Schuller, D Turkewitz
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Grünberg, P J Sterk
Jan 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M K Church

Related Concepts

Kloromin
Antihistamines, Classical
Histamine Release
Immunoglobulin E
Lung
Mast Cell
Kriptin

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