PMID: 6161310Jan 15, 1981Paper

Inhibition of histamine secretion from mast cells

Nature
M EnnisF L Pearce

Abstract

Histamine secretion from mast cells may be inhibited by elevated intracellular levels of cyclic AMP and by several anti-allergic drugs. These compounds are claimed to act directly on the calcium-gating mechanism activated by the anaphylactic reaction, preventing influx of Ca2+ from the external environment and so blocking exocytosis. To examine this hypothesis further, we have compared here the histamine secretion induced by immunoglobulin E-directed ligands in the presence and absence of added calcium and by the ionophore A23187. Exocytosis evoked by these former agents was originally considered to be almost totally dependent on extracellular calcium but recent studies have shown otherwise. In the absence of added cation, the agents act by mobilizing membrane-bound or intracellular stores of calcium. We show that here that a variety of anti-allergic drugs are potent inhibitors in the conditions used, suggesting that alternative explanations for their action must be sought.

References

Aug 15, 1977·Biochimica Et Biophysica Acta·C M Fewtrell, B D Gomperts
Sep 1, 1977·The Journal of Physiology·J C ForemanJ L Mongar
Feb 15, 1978·Biochemical Pharmacology·J H Baxter, R Adamik
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Aug 1, 1972·The Journal of Physiology·J C Foreman, J L Mongar
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Jan 1, 1980·International Archives of Allergy and Applied Immunology·M EnnisF L Pearce
Oct 1, 1980·British Journal of Pharmacology·M EnnisP M Weston

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Citations

Apr 1, 1982·Agents and Actions·A TrunehF L Pearce
Apr 1, 1983·Agents and Actions·M EnnisC T Dollery
Apr 1, 1984·Agents and Actions·P T Peachell, F L Pearce
Jan 1, 1986·Lung·S Y SoW K Lam
Apr 25, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Miyoko MatsushimaTsutomu Kawabe
Apr 1, 1983·Biochemical Pharmacology·B Havsteen
Apr 1, 1982·Immunopharmacology·A SchwartzE Middleton
Oct 1, 1981·Human Immunology·J A McIntyreW P Faulk
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Leonard BieloryTheoharis Theoharides
Sep 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M NabeR G Townley
Dec 1, 1987·British Journal of Clinical Pharmacology·A MiadonnaC Zanussi
Oct 21, 2018·British Journal of Pharmacology·Ekaterini Tiligada, Madeleine Ennis
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Aug 1, 1983·Zentralblatt für Veterinärmedizin. Reihe A·S Axelsson, J Luthman
Nov 2, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuanyuan DingLangchong He

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.