Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits

Journal of Alzheimer's Disease : JAD
Gao-Shang ChaiGong-Ping Liu

Abstract

There is accumulating evidence that decreased histone acetylation is involved in normal aging and neurodegenerative diseases. Recently, we found that ANP32A, a key component of INHAT (inhibitor of acetyltransferases) that suppresses histone acetylation, increased in aged and cognitively impaired C57 mice and expressing wild-type human full length tau (htau) transgenic mice. Downregulating ANP32A restored cognitive function and synaptic plasticity through upregulation of the expressions of synaptic-related proteins via increasing histone acetylation. However, there is no direct evidence that ANP32A can induce neurodegeneration and memory deficits. In the present study, we overexpressed ANP32A in the hippocampal CA3 region of C57 mice and found that ANP32A overexpression induced cognitive abilities and synaptic plasticity deficits, with decreased synaptic-related protein expression and histone acetylation. Combined with our recent studies, our findings reveal that upregulated ANP32A induced-suppressing histone acetylation may underlie the cognitive decline in neurodegenerative disease, and suppression of ANP32A may represent a promising therapeutic approach for neurodegenerative diseases including Alzheimer's disease.

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Citations

Feb 4, 2019·Journal of Cellular and Molecular Medicine·Shuo LiChang Peng
Jan 1, 2021·Ecotoxicology and Environmental Safety·Zhenkun GuoHuangyuan Li
Nov 9, 2021·Frontiers in Molecular Biosciences·Hani SabaieMaryam Rezazadeh

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