PMID: 8585762Sep 1, 1995Paper

Inhibition of HIV-1 in vitro by C-5 propyne phosphorothioate antisense to rev

Antiviral Research
O S LundJ E Hansen

Abstract

A 15-mer C-5 propyne modified phosphorothioate oligodeoxynucleotide antisense to rev was approximately 5-fold more effective in providing viral inhibition compared to a 28-mer unmodified phosphorothioate oligodeoxynucleotide targeted to the same sequence and previously shown to inhibit HIV-1 in a sequence-dependent manner. The antiviral effect was obtained by lipofection or simple addition of 0.2-1 microM modified oligodeoxynucleotide to the culture medium of H9 cells chronically infected with the HIV-1LAI isolate of human immunodeficiency virus type 1. We conclude that C-5 propyne oligodeoxynucleotides in accordance with previous findings by others are superior to unmodified phosphorothioates in providing inhibition of HIV-1 in a sequence-dependent manner and that this inhibition can be conferred by oligodeoxynucleotides in free solution.

References

Dec 1, 1991·Pharmacology & Therapeutics·C A SteinL Yakubov
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Citations

May 4, 2001·Antisense & Nucleic Acid Drug Development·L MeunierA C Roche
Apr 20, 2006·Antiviral Research·Arthur Van Aerschot
May 14, 2005·Antiviral Chemistry & Chemotherapy·Michael Markosian, Robyn M Hyde
Feb 26, 2010·Developmental Neuropsychology·Robert W ThatcherPhillip Defina

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