Inhibition of HIV replication by capsid mutant C6b

Biochemical and Biophysical Research Communications
R ShimanoA Adachi

Abstract

A Gag capsid mutant of human immunodeficiency virus type 1 (HIV-1) designated C6b was biologically and biochemically characterized with respect to its ability to suppress the replication of wild-type (wt) HIV. The C6b efficiently interfered with the replication of wt HIV-1 in the cleavage of Gag precursor, and also in the early replication process before or during viral DNA synthesis after viral penetration. The C6b Gag appeared to be unable to form chimeric multimers with HIV-2 Gag and failed to inhibit the replication of wt HIV-2.

References

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Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C T ChienS Fields
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T FolksK Sell
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Citations

Aug 9, 2002·AIDS Research and Human Retroviruses·Jianhua FangRoger J Pomerantz
Nov 30, 2004·Virology·Jianhua FangRoger J Pomerantz
Jul 24, 1998·Biochemical and Biophysical Research Communications·R ShimanoA Adachi
Jun 27, 1998·Biochemical and Biophysical Research Communications·R InubushiA Adachi

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