PMID: 2122146Jan 1, 1990Paper

Inhibition of HIV replication by naphthalenemonosulfonic acid derivatives and a bis naphthalenedisulfonic acid compound

Life Sciences
P MohanP S Sarin

Abstract

Several naphthalenemonosulfonic acid analogs and a bis naphthalenedisulfonic acid have been evaluated for anti-HIV activity in assays using H9 and MOLT-3 cells. Among the naphthalenemonosulfonic acids, a 4-amino-5-hydroxy compound and a 4,5-diamino compound showed low anti-HIV activity (upto 50% inhibition) at non-toxic doses. The bis naphthalenedisulfonic acid compound demonstrated significant suppression of HIV-1 antigen expression as measured by monoclonal antibodies to p17 (95%), p24 (94%) and syncytia inhibition (82%) at a dose of 20 micrograms/ml that was non-toxic to the host cells. The bis naphthalenedisulfonic acid analog represents a new class of compounds which may be effective in the treatment of HIV infected patients. The structure activity relationship and a probable mode of action of these compounds is discussed.

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Citations

Mar 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R Pauwels, E De Clercq
May 1, 1995·Immunopharmacology and Immunotoxicology·P S Sarin, A L Goldstein
Feb 15, 2005·Antiviral Research·A N VzorovR W Compans
Jul 1, 1994·Journal of Pharmaceutical Sciences·H C Chang, D R Flanagan
Sep 1, 1995·Journal of Pharmaceutical Sciences·H C Chang, D R Flanagan
Sep 30, 1992·Biochemical and Biophysical Research Communications·E Gruszecka-KowalikL H Zalkow
Sep 9, 2006·Brain Research Reviews·Petrea FridNatalija Popovic
Apr 1, 1995·Clinical Microbiology Reviews·E De Clercq

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