Inhibition of hormonal and behavioral effects of stress by tryptophan in rats

Nutritional Neuroscience
Sumera GulDarakhshan J Haleem

Abstract

Stress in known to alter hormonal systems. Pharmacological doses of tryptophan, the essential amino acid precursor of serotonin, increase circulating leptin and decrease ghrelin in normal healthy adults. Because systemically injected leptin inhibits stress-induced behavioral deficits and systemically injected serotonin modulates leptin release from the adipocytes, we used tryptophan as a pharmacological tool to modulate hormonal and behavioral responses in unstressed and stressed rats. Leptin, ghrelin, serotonin, tryptophan, and behavior were studied in unstressed and stressed rats following oral administration of 0, 100, 200, and 300 mg/kg of tryptophan. Following oral administration of tryptophan at a dose of 300 mg/kg, circulating levels of serotonin and leptin increased and those of ghrelin decreased in unstressed animals. No effect occurred on 24-hours cumulative food intake and elevated plus maze performance. Exposure to 2 hours immobilization stress decreased 24 hours cumulative food intake and impaired performance in elevated plus maze monitored next day. Serum serotonin decreased, leptin increased, and no effect occurred on ghrelin. Stress effects on serotonin, leptin, food intake, and elevated plus maze performance di...Continue Reading

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Citations

May 23, 2019·Nutritional Neuroscience·Darakhshan Jabeen Haleem, Khalid Mahmood
Dec 27, 2017·Thoracic Cancer·Shuang Sun, Jun Zhou
Nov 17, 2020·Frontiers in Synaptic Neuroscience·Eva Maria FritzDimitri De Bundel

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