Abstract
This study demonstrates that viable Mycoplasma pneumoniae cells inhibit catalase activity in several types of intact human cells as well as in solution. Human erythrocyte catalase was inhibited up to 72%, and the inhibition of catalase in human cultured skin fibroblasts, lung carcinoma epithelial cells, and ciliated epithelial cells from human nasal polyps ranged between 75 and 80%. UV light-killed mycoplasmas failed to inhibit catalase activity both in intact cells and in vitro. After M. pneumoniae infection of human cultured skin fibroblasts, the level of malonyldialdehyde, an indicator for membrane lipid peroxidation, was 3.5 times higher than in control fibroblasts. Virulent M. pneumoniae completely inhibited catalase activity in solution, whereas the nonvirulent strains had a lesser ability to inhibit catalase activity. These findings suggest that as a result of host cell catalase inhibition by M. pneumoniae, the toxicity of the hydrogen peroxide generated by the microorganism and the affected cell is enhanced, thereby inducing host cell damage.
References
Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Jun 1, 1979·The Journal of Infectious Diseases·H M FoyI D Allan
May 1, 1979·Infection and Immunity·E J HansenJ B Baseman
Jun 1, 1977·Infection and Immunity·M G GabridgeJ A Engelhardt
Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jul 1, 1976·Infection and Immunity·P C HuJ B Baseman
Sep 1, 1968·Journal of Bacteriology·O SobeslavskyR M Chanock
Mar 1, 1968·Journal of General Microbiology·R J Manchee, D Taylor-Robinson
Oct 15, 1971·Biochemical and Biophysical Research Communications·S Yatziv, H M Flowers
Jul 28, 1967·Annals of the New York Academy of Sciences·G Cohen, N L Somerson
Sep 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·R P Lipman, W A Clyde
Apr 1, 1981·Infection and Immunity·E J HansenJ B Baseman
Feb 1, 1983·Infection and Immunity·D K LeithJ B Baseman
Feb 1, 1983·European Journal of Clinical Investigation·J M WieselH Ben-Bassat
Sep 1, 1980·Infection and Immunity·D K Chandler, M F Barile
Jan 8, 1981·The New England Journal of Medicine·G H Cassell, B C Cole
Nov 1, 1981·Infection and Immunity·M BanaiS Razin
Mar 1, 1982·Infection and Immunity·D C KrauseJ B Baseman
Oct 1, 1982·Infection and Immunity·J B BasemanI Kahane
Aug 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·R M CHANOCKL HAYFLICK
May 1, 1971·Infection and Immunity·A M Collier, W A Clyde
Citations
Dec 1, 1989·Immunological Reviews·E Ruuth, F Praz
Jul 1, 1993·In Vitro Cellular & Developmental Biology. Animal·L T Van der VenW Den Otter
Feb 15, 1996·Nucleic Acids Research·H HilbertR Herrmann
Jan 9, 2009·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Hui-Lun ChenGyula Zaray
Jul 14, 2011·Proteomics·Ina Catrein, Richard Herrmann
Mar 5, 2016·PLoS Pathogens·Marta I SánchezAndy J Green
Sep 1, 1994·Journal of Periodontal Research·A JohanssonS E Holm
Jun 3, 1985·FEBS Letters·D Del PrincipeA Finazzi-Agro
Nov 15, 1996·Nucleic Acids Research·R HimmelreichR Herrmann
Jul 23, 2008·Infection and Immunity·Chirag KariyaBrian J Day
Jul 30, 2008·Expert Review of Anti-infective Therapy·Kyung-Yil Lee
Aug 30, 2000·Microbes and Infection·G Rawadi
Apr 1, 1986·Infection and Immunity·M AlmagorS Yatziv
May 1, 1985·Infection and Immunity·M AlmagorS Yatziv
Mar 1, 1988·Infection and Immunity·Y Y Chen, D C Krause
Aug 1, 1988·Infection and Immunity·D C Krause, Y Y Chen
Apr 1, 1987·Biochemical Medicine and Metabolic Biology·Y Tsuchiya, H Sugai
Feb 15, 1990·Archives of Biochemistry and Biophysics·B Meier, G G Habermehl
Jan 1, 1984·Annales de microbiologie·I KahaneA Reisch-Saada
Mar 21, 2007·Clinical Biochemistry·Fernanda Timm Seabra SouzaJanice Carneiro Coelho
Jul 12, 2011·BMC Veterinary Research·Frantisek VitulaJiri Pikula
Feb 29, 2008·Ecotoxicology and Environmental Safety·Zhenmei LüHang Min