PMID: 7993072Aug 1, 1994Paper

Inhibition of human adenoviruses by 1-(2'-hydroxy-5'-methoxybenzylidene)amino-3-hydroxyguanidine tosylate

Antiviral Research
M B HuiM D Trousdale

Abstract

Antiviral activities of four Schiff bases of aminohydroxyguanidine, designated ML1, ML4, ATL14 and LK11, were tested against human adenovirus types 5 and 8 (Ad5 and Ad8) in A549 cells by plaque reduction and virus yield reduction methods. Compound (ML1 1-(2'-hydroxy-5'-methoxybenzylidene)amino-3-hydroxyguanidine tosylate gave the best therapeutic indices (TC50/IC50) of 27.2 and 17.8 for Ad5 and Ad8, respectively. Pretreatment of cells with ML1 did not affect the adsorption nor the penetration of virus. Ultrastructure studies showed that only the drug treated infected cells had unidentified irregular shaped electron dense structures that might be drug altered viral macromolecules that were not assembled into complete infectious virus particles. Since these compounds have metal chelating properties, their antiviral activity may involve the early IA (EIA) gene which encodes a viral protein of 289 amino acid which has a zinc finger moiety that is required for its transactivation activity.

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Citations

May 1, 1996·Journal of Virological Methods·R MentelU Wegner
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Y FurutaK Shiraki
Mar 4, 2005·The Journal of Antimicrobial Chemotherapy·Paul R KinchingtonY Jerold Gordon
Feb 29, 2008·The Journal of Organic Chemistry·Tadeusz M KrygowskiPaolo Lazzeretti
Jul 13, 2006·The Journal of Physical Chemistry. a·A FilarowskiP E Hansen

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