Inhibition of human breast cancer cell invasion by siRNA against urokinase-type plasminogen activator

Cancer Investigation
Hong-Yan HuangAn-Gang Yang

Abstract

Urokinase plasminogen activator (uPA) correlates closely with breast cancer metastasis via triggering the degradation of divergent matrix proteins. Here, uPA was selectively knocked down in breast carcinoma MDA-MB-231 cells by siRNAs. The in vitro migration of MDA-MB-231 cells was effectively suppressed accompanied by a decrease in extracellular MMP-9 activities. The colony formation ability of MDA-MB-231 cells was inhibited following uPA knockdown, while the proliferation was not affected. The uPA knockdown in MDA-MB-231 cells caused significantly suppressed tumor metastasis in nude mice. Thus, siRNAs targeted to uPA have implications in the development of novel approaches to preventing breast cancer metastasis.

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Jan 6, 2012·Expert Opinion on Investigational Drugs·Swapna AsuthkarChristopher S Gondi
Feb 15, 2011·Expert Opinion on Drug Delivery·Ezharul Hoque Chowdhury
Dec 4, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Linlin Tang, Xiuzhen Han
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Jan 2, 2021·Critical Reviews in Oncology/hematology·Shokooh SalimimoghadamBehzad Baradaran
Aug 20, 2014·Journal of Agricultural and Food Chemistry·Shih-Chia LiuShih-Wei Wang

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