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Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis

European Journal of Biochemistry

Jan 15, 1988

Paul Andrew KarplusGeorg E Schulz

PMID: 3338461

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Abstract

Glutathione reductase from human erythrocytes was inhibited by incubation with the drugs 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea (HeCNU) under quasi-physiological conditions. For reference purposes, iodoacetamide was used for in...read more

Mentioned in this Paper

Glutathione Reductase
X-Ray Diffraction
NSC 29485
BiCNU
Nitrosourea Compounds
Crystallography
Paper Details
References
  • References13
  • Citations31
12
  • References13
  • Citations31
1234

Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis

European Journal of Biochemistry

Jan 15, 1988

Paul Andrew KarplusGeorg E Schulz

PMID: 3338461

DOI:

Abstract

Glutathione reductase from human erythrocytes was inhibited by incubation with the drugs 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea (HeCNU) under quasi-physiological conditions. For reference purposes, iodoacetamide was used for in...read more

Mentioned in this Paper

Glutathione Reductase
X-Ray Diffraction
NSC 29485
BiCNU
Nitrosourea Compounds

Related Papers

Paper Details
References
  • References13
  • Citations31
12
  • References13
  • Citations31
1234

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