Inhibition of human hemopoiesis by non-A, non-B hepatitis virus

Journal of Medical Virology
J B ZeldisH N Steinberg

Abstract

All etiologies of acute viral hepatitis are associated with a transient suppression of hemopoiesis and, rarely, with the development of aplastic anemia. Both hepatitis A and hepatitis B viruses directly inhibit the growth and differentiation of human bone marrow progenitor cells in vitro. We now report a similar effect of a non-A, non-B (NANB) hepatitis agent on human bone marrow progenitor cells. Three chimpanzees were inoculated with a putative NANB agent. Coded sera were blindly evaluated for their ability to affect human bone marrow colony formation in vitro. Sera obtained during the acute phase of NANB hepatitis inhibited the in vitro growth of human erythroid (CFU-E, BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells, compared with sera obtained before inoculation. Sera obtained after remission of both the biochemical and histological hepatitis and sera obtained from a chimpanzee who underwent biochemical but not histological remission did not inhibit the stem cell assays as much as the acute phase sera. These results suggest an approach to identifying the viremic phase of NANB hepatitis. Inhibition of human bone marrow proliferation appears to be a common property of all known hepatitis viruses.

References

Oct 1, 1978·Archives of Internal Medicine·D A CasciatoJ L Scott
Aug 1, 1986·The Journal of Clinical Investigation·J B ZeldisR P Gale
Apr 1, 1987·Transplantation·P G StockN L Ascher
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J B ZeldisH N Steinberg
Mar 1, 1973·The American Journal of Digestive Diseases·M NagarajuG Baumann
Jan 1, 1983·The American Journal of Medicine·J B ZeldisR P Gale
May 26, 1984·British Medical Journal·P PontissoC Brechot
Aug 12, 1983·Science·J L Romet-LemonneM Essex
Aug 25, 1951·British Medical Journal·G P JONES, E G EVANS
Apr 1, 1947·The American Journal of the Medical Sciences·H J ZIMMERMAN, C F LOWRY
Aug 1, 1946·The American Journal of the Medical Sciences·W P HAVENS, R E MARCK

❮ Previous
Next ❯

Citations

Jun 1, 1992·Annals of Hematology·F W BuschA Vallbracht
Sep 1, 1990·Baillière's Clinical Gastroenterology·N Sheron, G J Alexander
Dec 12, 2001·Journal of Pediatric Gastroenterology and Nutrition·P F Whitington, E M Alonso
Oct 31, 2012·Journal of Digestive Diseases·Lobna Y GhanemHisham R El-Khayat
Jun 1, 1991·Blood Reviews·S J Rosenfeld, N S Young
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reem GhalibYehuda Z Patt
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J B Zeldis
Jan 1, 1992·Immunopharmacology and Immunotoxicology·V G VillarrubiaJ M Herrerias
Jun 16, 2001·Hematology·DÜZGÜN ÖzatliSEMRA Dündar
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa M SedgerLisa Hyland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.