Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions.

Journal of Virology
K MoellingH Diringer

Abstract

The reverse transcriptase (RT) activity of human immunodeficiency virus type 1 and other retroviruses is closely associated with a hybrid-degrading RNase H activity which is essential for retroviral replication. We have analyzed the effect of sulfated polysaccharides on human immunodeficiency virus type 1 recombinant RT and RNase H activities in vitro. Heparin, dextran sulfates, and xylan polysulfate were found to be much more potent inhibitors of RNase H than of RT and exhibit 50% infective doses of 0.04 to 0.1 micrograms/ml (corresponding to 0.1 to 25 nM) which is up to 5,000-fold more efficient than that for RT. Inhibitors of RNase H activity are attractive as antiviral drugs.

References

Oct 1, 1988·AIDS Research and Human Retroviruses·F LoriU Bertazzoni
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·V R Prasad, S P Goff
Feb 1, 1984·The Journal of General Virology·B EhlersH Diringer
Aug 1, 1984·The Journal of General Virology·B Ehlers, H Diringer

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Citations

Sep 12, 2002·Expert Opinion on Therapeutic Targets·M L AndréolaS Litvak
May 11, 2011·Acta Biologica Hungarica·Hoda Anwer MansourM H Kdodier
Jun 6, 1994·Annals of the New York Academy of Sciences·H DiringerU Oberdieck
Jan 1, 1996·AIDS Research and Human Retroviruses·P ClayetteD Dormont
Nov 13, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara UrbinatiMarco Rusnati
Jan 7, 2006·Oligonucleotides·Eckart MatthesMartin Von Janta-Lipinski
Apr 1, 2011·Biotechnology Progress·A Catarina GuedesF Xavier Malcata
Jun 1, 1992·AIDS Research and Human Retroviruses·R F SchinaziP M Feorino
Apr 5, 2002·Phytotherapy Research : PTR·Byung-Sun MinMasao Hattori
Dec 14, 2001·Journal of Biochemical and Biophysical Methods·Mahmoud HuheihelShoshana Malis Arad
Mar 22, 1996·Biochemical Pharmacology·I W AlthausF Reusser
Nov 14, 1997·General Pharmacology·M Witvrouw, E De Clercq
Jun 6, 2000·Advanced Drug Delivery Reviews·G GiammonaG Pitarresi
Nov 1, 1991·Antimicrobial Agents and Chemotherapy·W B OffenspergerW Gerok
Apr 1, 1995·Clinical Microbiology Reviews·E De Clercq
Jan 1, 1990·Pharmacology & Therapeutics·U Wintersberger
Sep 1, 1994·Immunology Letters·B Thiele, F Steinbach
Jun 22, 2019·International Journal of Biological Macromolecules·Ligia Carla Faccin-GalhardiCarlos Nozawa
Sep 8, 2018·Chemical Reviews·Allie Y ChenSeth M Cohen
May 23, 2006·Journal of Chemical Information and Modeling·Tulay Ercanli, Donald B Boyd

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