PMID: 8955852Dec 1, 1996Paper

Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobene

Antiviral Research
S M HallidayR W Buckheit

Abstract

The anti-HIV sulfonated dye, resobene, was found to be a potent inhibitor of the attachment of HIV to target cells, the fusion of envelope- and CD4-expressing cells, and the cell-to-cell transmission of virus. Resobene inhibited the infection of phenotypically distinct, established human cell lines and fresh human peripheral blood lymphocytes and macrophages by laboratory-derived isolates of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), and a panel of biologically diverse primary clinical isolates, including syncytium-inducing and non-syncytium-inducing viruses and strains representative of the various virus clades found worldwide. The compound was also active against all drug-resistant virus isolates tested. Cell-based and biochemical mechanism of action studies demonstrated that the compound inhibits the attachment of infectious virus and fusion of virus-infected cells to uninfected target cells by binding to the cationic V3 loop of the envelope glycoprotein. Resobene effectively inhibited the infection of cell populations which do and do not express cell surface CD4. Resobene prevented infection of the cervical epithelial cell line ME180, suggesting the compound may effectively act as a topical microbicide ...Continue Reading

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·E Gruszecka-KowalikL H Zalkow
Jan 11, 1992·Journal of Acquired Immune Deficiency Syndromes : JAIDS·D J ClantonJ P Bader
Aug 1, 1991·The Journal of Experimental Medicine·Q J Sattentau, J P Moore
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E S DaarD D Ho
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K JavaherianS D Putney
May 12, 1995·Journal of Medicinal Chemistry·E M BurgessR D Haugwitz

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Citations

Aug 29, 2012·AIDS Research and Human Retroviruses·Phalguni GuptaAlexander M Cole
Sep 8, 2011·Antimicrobial Agents and Chemotherapy·Karen Watson BuckheitRobert W Buckheit
Oct 16, 2004·Expert Review of Anti-infective Therapy·Jim A Turpin
Aug 2, 2002·Expert Opinion on Investigational Drugs·Jim A Turpin
Jun 15, 2005·Angewandte Chemie·Hang Yin, Andrew D Hamilton

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