Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Farida LaritStephen J Cutler

Abstract

Monoamine oxidases (MAOs) are outer mitochondrial membrane flavoenzymes. They catalyze the oxidative deamination of a variety of neurotransmitters. MAO-A and MAO-B may be considered as targets for inhibitors to treat neurodegenerative diseases and depression and for managing symptoms associated with Parkinson's and Alzheimer's diseases. The objective was to evaluate the inhibitory effect of Hypericum afrum and Cytisus villosus against MAO-A and B and to isolate the compounds responsible for the MAO-inhibitory activity. The inhibitory effect of extracts and purified constituents of H. afrum and C. villosus were investigated in vitro using recombinant human MAO-A and B, and through bioassay-guided fractionation of ethyl acetate fractions of areal parts of the two plants collected in northeastern Algeria. In addition, computational protein-ligand docking and molecular dynamics simulations were carried out to explain the MAO binding at the molecular level. The ethyl acetate (EtOAc) fractions of H. afrum and C. villosus showed the highest MAO inhibition activity against MAO A and B with IC50 values of 3.37 µg/ml and 13.50 µg/ml as well as 5.62 and 1.87 µg/ml, respectively. Bioassay-guided fractionation of the EtOAc fractions resulte...Continue Reading

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Citations

Feb 13, 2019·Current Topics in Medicinal Chemistry·Priyanka DhimanAnurag Khatkar
Jul 2, 2019·Central Nervous System Agents in Medicinal Chemistry·Idalet EngelbrechtAnél Petzer
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Apr 12, 2020·Journal of Clinical Medicine·Mehdi Sharifi-RadJavad Sharifi-Rad
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Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Narayan D ChaurasiyaBabu L Tekwani
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Farida LaritMohammed M Ghoneim
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marjan TalebiSaeed Samarghandian

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