Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study

Brain : a Journal of Neurology
Ulf ZiemannW Paulus

Abstract

The non-invasive technique of focal transcranial magnetic stimulation (TMS) was used in six healthy volunteers to evaluate the effect of ethanol on four aspects of human central motor system excitability: (i) threshold intensity for the motor evoked potential (MEP) in the resting and active abductor digiti minimi muscle (ADM); (ii) variation of MEP amplitude with increasing stimulus intensity; (iii) duration of the TMS induced cortical silent period (CSP); (iv) intracortical inhibition and facilitation after paired magnetic stimulation. In addition, the maximum M wave (Mmax) after supra-maximal electrical ulnar nerve stimulation and the peripheral silent period (PSP) have been tested as parameters of peripheral motor excitability. Baseline measurements were compared with data obtained on a mean ethanol blood concentration of 0.8 ml/l. Resting and active motor thresholds remained unchanged. Also, the absolute Mmax values and the MEP/Mmax ratio at various TMS intensities were not affected by ethanol. The mean CSP duration was prolonged by up to 35 ms while the PSP duration showed no change. The principal effect of ethanol was an enhancement of intracortical inhibition and a suppression of intracortical facilitation. These results...Continue Reading

Citations

Dec 19, 2009·Psychopharmacology·Sylco S HoppenbrouwersDennis J L G Schutter
Oct 14, 2004·Experimental Brain Research·Filippo BrighinaBrigida Fierro
May 31, 2006·Experimental Brain Research·Milos Ljubisavljevic
Feb 25, 2009·Journal of Neural Transmission·Xingbao LiMark S George
Dec 5, 2006·Archives of Physical Medicine and Rehabilitation·Michelle L Harris-Love, Leonardo G Cohen
May 24, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fortunato BattagliaMichele Buemi
May 12, 2004·Neuroscience Letters·Claudia Koerner, Hans-Michael Meinck
Sep 22, 1998·Electroencephalography and Clinical Neurophysiology·P M Rossini, S Rossi
Nov 24, 2001·Journal of the Neurological Sciences·T KatayamaO Yahara
Apr 29, 1998·Epilepsy Research·U ZiemannW Paulus
Feb 4, 1998·Electroencephalography and Clinical Neurophysiology·U ZiemannW Paulus
Aug 4, 1999·Neurophysiologie clinique = Clinical neurophysiology·A Salerno, M Georgesco
Jun 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Valerie Reid
May 29, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A SalernoM Georgesco
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J LiepertC Weiller
Jan 22, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jose Rafael RomeroAlvaro Pascual-Leone
Jun 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P ManganottiA Fiaschi
May 10, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Carlo Alberto TassinariRoberto Michelucci
Jun 14, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Joachim LiepertC Weiller
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A GorslerJ Liepert
Jul 13, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C TrompettoG Abbruzzese
Sep 15, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·L G CohenC Butefisch
Sep 15, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A Pascual-LeoneM D Catalá
Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Babak Boroojerdi
Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Giovanni Abbruzzese, Carlo Trompetto
Aug 4, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·P A PaineS Hamdy
Jul 22, 2009·Clinical Neuropharmacology·Pierpaolo BusanGiovanna Pelamatti
Nov 28, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·V DelvauxA Maertens de Noordhout
Feb 24, 2011·Neurorehabilitation and Neural Repair·Michelle L Harris-LoveLeonardo G Cohen
Jan 5, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline LückeUlf Ziemann
Jun 27, 2008·The Journal of ECT·Rita NavarroDavid Avery
Jul 23, 2005·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·Mamede de CarvalhoMichael Swash
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Filippo Sean GiorgiUbaldo Bonuccelli
Jan 29, 2016·Journal of Epilepsy Research·Jung Hwa LeeSeung Bong Hong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.