Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Heloísa Della Coletta FrancescatoTerezila M Coimbra

Abstract

Cisplatin (CP)-induced renal damage is associated with inflammation. Hydrogen sulphide (H2S) is involved in models of inflammation. This study evaluates the effect of DL-propargylglycine (PAG), an inhibitor of endogenous H2S formation, on the renal damage induced by CP. The rats were injected with CP (5 mg/kg, i.p.) or PAG (5 mg/kg twice a day, i.p.) for 4 days, starting 1 h before CP injection. Control rats were injected with 0.15 M NaCl or PAG only. Blood and urine samples were collected 5 days after saline or CP injections for renal function evaluation. The kidneys were removed for tumour necrosis factor (TNF)-α quantification, histological, immunohistochemical and Western blot analysis. The cystathionine γ-lyase (CSE) activity and expression were assessed. The direct toxicity of H(2)S in renal tubular cells was evaluated by the incubation of these cells with NaHS, a donor of H2S. CP-treated rats presented increases in plasma creatinine levels and in sodium and potassium fractional excretions associated with tubulointerstitial lesions in the outer medulla. Increased expression of TNF-α, macrophages, neutrophils and T lymphocytes, associated with increased H2S formation rate and CSE expression, were also observed in the outer...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·S M O'ReillyR D Rubens
Jan 1, 1983·Annual Review of Biochemistry·A J Cooper
Aug 1, 1981·The American Journal of Physiology·R SafirsteinC Shapiro
Jan 1, 1982·Kidney International·S ChopraB F Trump
Apr 1, 1993·Endocrine Reviews·R A Schwartzman, J A Cidlowski
Apr 1, 1996·The American Journal of Physiology·W LieberthalJ Levine
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Lebwohl, R Canetta
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
Apr 26, 2003·Journal of Toxicology and Environmental Health. Part a·T XiaoA Salahudeen
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·H N HAUGEN
Oct 11, 2003·Archives of Toxicology·David Sheikh-HamadBellamkonda K Kishore
Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M RodriguesJ R Perussi
May 1, 2004·Kidney & Blood Pressure Research·Heloísa D Coletta FrancescatoMaria de L P Bianchi
Jul 17, 2004·Journal of Neurochemistry·Matthew WhitemanPhilip K Moore
Mar 9, 2005·British Journal of Pharmacology·Madhav BhatiaPhilip K Moore
Apr 9, 2005·American Journal of Physiology. Renal Physiology·Shenyang LiDidier Portilla
May 3, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ling LiPhilip K Moore
May 25, 2005·Contributions to Nephrology·Takashi TaguchiMohammed S Razzaque
Feb 21, 2006·Current Opinion in Pharmacology·Ling LiPhilip K Moore
Jun 6, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R A VolpiniT M Coimbra
Jun 19, 2007·Hearing Research·Dennis T Ries, Jeffery J DiGiovanni
Jul 21, 2007·Kidney & Blood Pressure Research·Andréa G C FlávioTerezila M Coimbra
Sep 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·John W ElrodDavid J Lefer
Sep 22, 2007·Trends in Pharmacological Sciences·John L Wallace
Oct 20, 2007·Nature Reviews. Drug Discovery·Csaba Szabó
Oct 25, 2007·Biochemical Society Transactions·L Li, P K Moore
Jul 1, 2008·European Journal of Pharmacology·Thiago M CunhaFernando Q Cunha
Aug 6, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Pinpat TripataraChristoph Thiemermann
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniela Dal-SeccoFernando Q Cunha
Sep 18, 2008·American Journal of Nephrology·Carla de Lima E SantosMirian A Boim
Dec 26, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Y-Y P Mok, P K Moore
Apr 8, 2009·The Journal of Clinical Investigation·Craig BrooksZheng Dong
Apr 21, 2009·Journal of Cellular and Molecular Medicine·Matthew Whiteman, Philip K Moore
Apr 21, 2009·Gastroenterology·John L WallaceGary R Martin
Jul 3, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Gary R MartinJohn L Wallace
Jul 25, 2009·Journal of the American Society of Nephrology : JASN·Eelke M BosHarry van Goor

❮ Previous
Next ❯

Citations

Feb 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandra F Perna, Diego Ingrosso
Feb 15, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H D C FrancescatoT M Coimbra
May 19, 2011·Archives of Toxicology·Heloísa Della Coletta FrancescatoTerezila Machado Coimbra
Nov 29, 2013·Kidney International·Kai SongLi-Fang Hu
May 31, 2014·Kidney International·Balakuntalam S Kasinath
Mar 28, 2012·Expert Opinion on Therapeutic Targets·Jack R RiversMadhav Bhatia
Feb 7, 2015·Nitric Oxide : Biology and Chemistry·Anne M KoningHarry van Goor
Dec 11, 2014·Canadian Journal of Physiology and Pharmacology·Lindsei K SarnaKarmin O
Oct 21, 2016·Antioxidants & Redox Signaling·Denis FeliersBalakuntalam S Kasinath
Jun 25, 2016·Mediators of Inflammation·Mi LiuTianxin Yang
Nov 3, 2016·Frontiers in Pharmacology·Xu Cao, Jin-Song Bian
Sep 7, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Abel D AngMadhav Bhatia
Jan 9, 2020·Expert Opinion on Drug Safety·Motahareh Mahi-BirjandIman Karimzadeh
Nov 1, 2020·Molecular and Cellular Biochemistry·Andreia Mara MoreiraSilvia Graciela Ruginsk
Jun 19, 2021·World Journal of Clinical Cases·Alexandru Scafa-UdristeMaria Dorobantu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

Related Papers

British Journal of Pharmacology
Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Heloísa D C FrancescatoT M Coimbra
© 2021 Meta ULC. All rights reserved