Inhibition of hydroxyapatite dissolution by ovalbumin as a function of pH, calcium concentration, protein concentration and acid type

Caries Research
C A HemingwayMichele E Barbour

Abstract

Hydroxyapatite is the main constituent of the dental hard tissues, and in vivo its dissolution in acids leads to the pathological condition of dental erosion. Food proteins which inhibit hydroxyapatite dissolution may find application as erosion-reducing agents in food and drink products. The aim of this study was to investigate the egg protein ovalbumin as a potential inhibitor of hydroxyapatite dissolution in acidic solutions, with conditions representative of dental erosion. The dissolution rate of hydroxyapatite discs was measured in an acidic solution as a function of pH, calcium concentration, ovalbumin concentration and acid type. All experiments were performed in triplicate. 0.2% w/v ovalbumin significantly reduced the dissolution rate in citric acid by 50-75% over the pH range 2.80-4.00, and by 45-60% in solutions with calcium concentrations of up to 20 mM (p < 0.05). The effect was persistent for several rinses after the initial exposure to the protein. 0.02% w/v ovalbumin significantly reduced the dissolution of hydroxyapatite in citric acid by 30-55%. Ovalbumin did not, however, statistically significantly reduce the hydroxyapatite dissolution rate in malic or lactic acids. The effect is ascribed to adsorption and p...Continue Reading

Citations

Apr 27, 2012·European Journal of Nutrition·Xiaojie Wang, Adrian Lussi
Jul 31, 2013·Clinical Oral Investigations·Arzu Aykut-YetkinerThomas Attin
Apr 16, 2014·Archives of Oral Biology·Dusa VukosavljevicWalter L Siqueira
Oct 27, 2015·Journal of Dentistry·Taísa Ribas DelecrodeMarília Afonso Rabelo Buzalaf
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Satish S SinghPrashant N Kumta
Sep 3, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Hsiu-Ying Chung, Kuo-Chen Huang
Jun 3, 2011·Caries Research·M E BarbourR P Shellis
Jun 3, 2011·Caries Research·R P ShellisA Lussi
Jul 23, 2015·Brazilian Dental Journal·Stella S FerreiraMaria Angela Pita Sobral
Nov 18, 2015·Clinical Oral Investigations·Parastu Azadi-SchossigThomas Attin
Sep 26, 2020·Clinical Oral Investigations·Melissa Thiemi KatoMarília Afonso Rabelo Buzalaf
Apr 6, 2017·International Journal of Clinical Pediatric Dentistry·Mithra N Hegde, Ankit R Sajnani
Nov 11, 2020·Caries Research·Tatiana MartiniMarília Afonso Rabelo Buzalaf

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