PMID: 59001Dec 1, 1975

Inhibition of hypersensitivity reactions by soluble derivatives of baicalein

Japanese Journal of Pharmacology
H NagaiA Koda

Abstract

Baicalein, a flavonoid, is anti-allergic but only slightly soluble in water. The soluble derivatives of baicalein, disodium baicalein-6-phosphate (BPS) and sodium baicalein-6-sulfate (BSS), were synthesized and examined regarding their effects on hypersensitivity reactions. These derivatives inhibited type I and II reactions as classified by Coombs and Gell. The Arthus reaction belonging to type III reaction, however, was hardly affected with either BPS or BSS. The experimental asthma caused by passive systemic anaphylaxis in guinea pigs was prevented with application of BPS. Thus even by the oral route, BPS appears to be clinically applicable to extensive allergy related diseases.

Citations

Jan 1, 1988·Archives of Oto-rhino-laryngology·K Ikeda, T Takasaka
Dec 1, 1987·Journal of Ethnopharmacology·M J Alcaraz, M L Ferrándiz
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·S YamamotoS Watanabe-Kohno
Nov 6, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wing P ChanMeng-Yi Bai
Mar 17, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·L Bielory, K Lupoli
Jan 1, 1988·Pharmazie in unserer Zeit·J Spilková, J Hubík
Jun 21, 2019·Scientific Reports·Bernie Byunghoon ParkYoung Ho Jeon

Related Concepts

Corophyllin
Anaphylaxis
Antigens
Arthus Reaction
Asthma
Kloromin
Bioflavonoids
Cavia porcellus
Hemolysin
Histamine Release

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