Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

Journal of the American Society of Nephrology : JASN
Peter HillPatrick Maxwell

Abstract

Acute renal failure resulting from hypoperfusion and hypoxia is a significant clinical problem. Hypoxia activates the heterodimeric transcription factor hypoxia inducible factor (HIF), leading to changes in gene expression that promote tissue adaptation and survival. To determine whether HIF may protect the kidney from ischemia-reperfusion injury, we subjected hif1a(+/-) and hif2a(+/-) mice to renal ischemia-reperfusion injury. Injury was substantially more severe in hif(+/-) than in littermate controls, consistent with a protective role for HIF. Because wild-type mice exhibited submaximal HIF accumulation in response to no-flow ischemia, we tested compounds that might augment the protective HIF response following ischemia-reperfusion in these animals. We found that l-mimosine and dimethyloxalylglycine, two small molecules that activate HIF by inhibiting HIF hydroxylases, protected mouse kidneys from ischemia-reperfusion injury. Therefore, pharmacological activation of HIF may offer an effective strategy to protect the kidney from ischemic injury.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jun 2, 1995·The Journal of Biological Chemistry·A P LevyM A Goldberg
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·J D FirthP J Ratcliffe
Apr 25, 1997·The Journal of Biological Chemistry·C W PughP J Ratcliffe
Jan 10, 1998·The Journal of Biological Chemistry·F J LeeM Vaughan
Dec 23, 1999·Current Opinion in Structural Biology·C J Schofield, Z Zhang
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J PengG H Fong
Oct 6, 2000·The Journal of Clinical Investigation·G L Semenza
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Joseph V Bonventre
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Christian RosenbergerKai-Uwe Eckardt
Mar 12, 2003·Cell·Thorsten CramerRandall S Johnson
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christina WarneckeKai-Uwe Eckardt
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Makiko MatsumotoMasaomi Nangaku
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre, Joel M Weinberg
Jul 30, 2003·The Journal of Biological Chemistry·Martin O LeonardCormac T Taylor
Aug 13, 2003·Kidney International·Christian RosenbergerKai-Uwe Eckardt
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
May 4, 2004·Nature Reviews. Molecular Cell Biology·Christopher J Schofield, Peter J Ratcliffe
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Jul 31, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Lei XiRakesh C Kukreja
Aug 21, 2004·The Journal of Physiology·Malgorzata MilkiewiczStuart Egginton
Mar 23, 2005·Kidney International·Krissanapong ManothamMasaomi Nangaku
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rob HeltonCarrolee Barlow
Jul 28, 2005·Developmental Neuroscience·Ruiqiong RanFrank R Sharp
Sep 15, 2005·Experimental Physiology·Patrick H Maxwell
Nov 1, 2005·Nature Clinical Practice. Cardiovascular Medicine·Derek M Yellon, Derek J Hausenloy
May 23, 2006·Nature Reviews. Neuroscience·Jeffrey M Gidday
Jun 10, 2006·Journal of the American Society of Nephrology : JASN·Wanja M BernhardtKai-Uwe Eckardt
Mar 9, 2007·Journal of the American Society of Nephrology : JASN·Ichiro KojimaMasaomi Nangaku

❮ Previous
Next ❯

Citations

Mar 8, 2012·Langenbeck's Archives of Surgery·Judit KissMartin Schneider
Nov 10, 2009·Pflügers Archiv : European journal of physiology·Monique SilterDörthe M Katschinski
Aug 10, 2012·Pflügers Archiv : European journal of physiology·Yohannes HagosBirgitta C Burckhardt
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Jan 24, 2009·Nature Reviews. Drug Discovery·Peter FraislPeter Carmeliet
Dec 17, 2009·Nature Reviews. Nephrology·Toshio Miyata, Charles van Ypersele de Strihou
Nov 24, 2012·Pediatric Research·Stacey J ElleryHayley Dickinson
Sep 10, 2009·Antioxidants & Redox Signaling·Sarah K HartenPatrick H Maxwell
Jun 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian RosenbergerSamuel N Heyman
Jun 25, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sven KroeningMargarete Goppelt-Struebe
Sep 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Young Rim SongKi Young Na
Jul 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zhendi WangWanja M Bernhardt
Mar 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiaofang YuXiaoqiang Ding
Sep 26, 2009·Current Opinion in Nephrology and Hypertension·Tetsuhiro Tanaka, Masaomi Nangaku
Aug 22, 2012·Clinical and Experimental Pharmacology & Physiology·Masaomi NangakuKai-Uwe Eckardt
Sep 26, 2008·American Journal of Physiology. Renal Physiology·Timothy A SuttonPierre C Dagher
Sep 6, 2012·American Journal of Nephrology·Prashant JamadarkhanaShailesh Deshpande
Oct 23, 2012·American Journal of Respiratory Cell and Molecular Biology·Stephen FröhlichPaul McLoughlin
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Jan 25, 2012·The Journal of Clinical Investigation·Almut GrenzHolger K Eltzschig
Mar 18, 2009·Arthritis Research & Therapy·Kathryn M OliverEoin P Cummins
Apr 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Samuel N HeymanChristian Rosenberger
Feb 10, 2011·PLoS Computational Biology·Michael HawrylyczJyl Boline
Sep 17, 2011·Journal of the American Society of Nephrology : JASN·Gunnar SchleyCarsten Willam
Mar 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yujiro KidaIkuyo Yamaguchi
May 3, 2014·The Journal of Clinical Investigation·Pinelopi P KapitsinouVolker H Haase
Oct 3, 2014·BioMed Research International·Andreas HabertheuerDominik Wiedemann
Nov 2, 2014·Nature Reviews. Drug Discovery·Holger K EltzschigSean P Colgan
Mar 8, 2013·American Journal of Physiology. Renal Physiology·Yi FangXiaoqiang Ding
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·W M BernhardtK-U Eckardt
Feb 10, 2016·Clinical and Experimental Nephrology·Tetsuhiro Tanaka
Dec 15, 2015·Nature Reviews. Nephrology·Patrick H Maxwell, Kai-Uwe Eckardt
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katrin SchindlerGunter Wolf
Nov 19, 2015·Microbiology and Immunology·Eszter TubolyHidechika Okada
Mar 15, 2013·Kidney International·Toshio MiyataCharles van Ypersele de Strihou
Aug 2, 2012·Pharmacology & Therapeutics·Veerle MatheeussenIngrid De Meester

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Wanja M BernhardtKai-Uwe Eckardt
Proceedings of the National Academy of Sciences of the United States of America
Wanja M BernhardtK-U Eckardt
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Young Rim SongKi Young Na
American Journal of Physiology. Renal Physiology
Kuniko KimuraYoshihiko Saito
© 2021 Meta ULC. All rights reserved