PMID: 8614284Jan 1, 1996Paper

Inhibition of hypoxic coronary vasoconstriction by pinacidil

Life Sciences
Stephen T O'Rourke

Abstract

Acute hypoxia causes constriction of isolated coronary arteries from several species. The present study was designed to test whether pinacidil, a potassium channel opener, inhibits hypoxia-induced contraction of porcine isolated coronary arteries. Coronary arterial rings were suspended in organ baths for isometric tension recording. Hypoxic contractions were evoked by rapidly changing gas mixture from 95% O2/5% CO2 to 95% N2/5% CO2 in preparations partially contracted with KCl. Pretreatment with pinacidil (10(-6) to 10(-4) M) caused concentration-dependent inhibition of the contractile response to hypoxia. The inhibitory effect of pinacidil was attenuated by the K ATP channel blocker, glibenclamide (10(-6) M). In rings contracted with acetylcholine, glibenclamide caused a rightward shift in the concentration-response curve to pinacidil while having no effect on the vasorelaxant responses to sodium nitroprusside and diltiazem, thus confirming the specificity of glibenclamide for potassium channel opener-mediated responses, Taken together, the data indicate that pinacidil prevents hypoxia-induced contraction of porcine coronary arteries, and that the effect of pinacidil may be mediated by the opening of glibenclamide-sensitive po...Continue Reading

References

Mar 1, 1992·The American Journal of Physiology·P A Pappone, M T Lucero
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Feb 1, 1991·Journal of Molecular and Cellular Cardiology·J T ShepherdP M Vanhoutte
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J R de WeilleM Lazdunski
Jul 1, 1985·The Journal of Physiology·G M Rubanyi, P M Vanhoutte
Sep 22, 1994·European Journal of Pharmacology·J P DumasJ F Giudicelli
Feb 1, 1994·Trends in Pharmacological Sciences·R M Wadsworth
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·G Edwards, A H Weston

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Citations

Aug 1, 2000·Kidney International·C Westenfelder, R L Baranowski

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