Inhibition of immunological function mediated DNA damage of alveolar macrophages caused by cigarette smoke in mice

Inhalation Toxicology
Takahiro IshidaMinoru Takeuchi

Abstract

Exposure to cigarette smoke impairs the pulmonary immune system, including alveolar macrophage function, although the mechanisms by which this occurs are not fully elucidated. This study investigates the effect of cigarette smoke exposure on the antigen-presenting activity of alveolar macrophages, which is required for antigen-specific response to T cells. C57BL/6 mice were exposed to cigarette smoke for 10 days using a Hamburg II smoking machine, and alveolar macrophages were obtained by bronchoalveolar lavage. The antigen-presenting activity of alveolar macrophages was significantly inhibited in mice exposed to cigarette smoke compared with mice not exposed to cigarette smoke. Major histocompatibility complex class II cell surface molecule-positive cells, B7-1 molecule-positive cells, and interleukin-1beta messenger RNA gene expression in alveolar macrophages were significantly decreased in mice exposed to cigarette smoke compared with mice not exposed to cigarette smoke. In contrast, DNA damage and generation of superoxide and hydrogen peroxide in alveolar macrophages were significantly increased by cigarette smoke exposure. These results suggest that inhibition of the antigen-presenting activity of alveolar macrophages may ...Continue Reading

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Citations

Dec 29, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Andrew J GhioMichael C Madden
Apr 13, 2011·PLoS Genetics·Daniel MenendezMichael A Resnick
Jun 16, 2015·Molecular Immunology·David A RubensteinWei Yin
Jun 17, 2014·Inhalation Toxicology·Masayuki ItohKazutetsu Aoshiba
Jan 1, 2011·Toxicological and Environmental Chemistry·Cynthia A Leifer, Rodney R Dietert

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