Inhibition of in vivo 3H-spiperone binding by the proposed antipsychotic Des-Tyr1-gamma-endorphin

European Journal of Pharmacology
N W PedigoH I Yamamura

Abstract

The proposed antipsychotic neuropeptide des-tyrosine1-gamma-endorphin (DT gamma E, beta LPH62,77) inhibits in vivo 3H-spiperone binding in the hypothalamus, corpus striatum and mesolimbic areas of rat brain. The neuroleptic drug haloperidol produces similar effects in these areas as well as in frontal cortex, but is considerably more potent than DT gamma E. Correspondingly, haloperidol produces postural and motor abnormalities not seen with DY gamma E. These data together with the results from previous in vitro studies suggest DT gamma E might act indirectly, having a selective neuroleptic-like action at 3H-spiperone binding sites.

References

Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·U Havemann, K Kuschinsky
May 2, 1980·European Journal of Pharmacology·W H GispenD de Wied
May 7, 1982·European Journal of Pharmacology·R A Lahti, D D Gay
Apr 8, 1983·European Journal of Pharmacology·E E CoddA Witter
Jan 1, 1983·Vision Research·J E DowlingK J Watling
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·A D CrockerJ M Crocker
Dec 11, 1991·Pharmacology, Biochemistry, and Behavior·J K RowlettM T Bardo
Jun 1, 1982·Psychiatry Research·H Y MeltzerA Robertson
Jan 1, 1980·Peptides·G A OlsonD H Coy
May 1, 1982·Peptides·T L O'Donohue, D M Dorsa
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Capasso, A Loizzo
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Van Buskirk, J E Dowling
Jan 1, 1982·Annals of the New York Academy of Sciences·J MetzH Y Meltzer
Jan 1, 1982·Annals of the New York Academy of Sciences·J M van ReeH M van Praag

Related Concepts

Antipsychotic Effect
Behavior, Animal
Endorphins
Brain
Waxy Flexibility
Peptide Fragments
Butyrophenones
Blepharoptosis
Chromosome Aberrations
Haldol

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