Nov 1, 1975

Inhibition of induced pinocytosis in Amoeba proteus by membrane stabilizing drugs

Acta Physiologica Scandinavica
J O JosefssonS E Hansson

Abstract

The effect of membrane stabilizing drugs on cation induced pinocytosis was studied in Amoeba proteus. Initially the presence of local anesthetic drugs during a pinocytosis cycle had a stimulating effect on channel formation, however, the capacity to develop pinocytotic channels was reversibly inhibited after a period of treatment with these drugs. Imipramine, vinblastine and the phenothiazines had effects similar to local anaesthetics. The local anesthetics inhibited pinocytosis in the following order: dibucaine greater than tetracaine greater than bupivacaine greater than lidocaine greater than procaine, and the phenothiazines: thioridazine greater than prochlorperazine greater chlorpromazine greater than prometazine. Pinocytosis, when induced by Na+ or tris, was more affected by the drugs and by calcium binding agents than pinocytosis induced by K+. After pretreatment with inhibitory concentration of dibucaine (3 x 10(-4) M) the depolarization of the membrane and the conductance increase during pinocytosis were normal, while the increase of oxygen uptake during the pincoytosis cycle was abolished. Addition of Ca++ before, during or after dibucaine treatment decreased the effect of the drug. Conversely, in dibucaine-treated ce...Continue Reading

  • References18
  • Citations9

Mentioned in this Paper

Antipsychotic Effect
Amoeba proteus
Vinblastine
Depression, Chemical
Calcium
Phenothiazine
Dibucaine
Amoeba genus
Potassium
Uptake

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