PMID: 2109194Apr 1, 1990Paper

Inhibition of induction of adaptive response by o-vanillin in Escherichia coli B

Mutation Research
K WatanabeY Shirasu

Abstract

Mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were strongly enhanced in the presence of o-vanillin in E. coli B. The enhancement was also observed in uvrA, umuC, recA, polA, or alkB mutants. This effect was lower in an alkA mutant, but was restored in an alkA umuC double mutant. By contrast, the enhancing effect was almost blocked in an ada and ada umuC double mutant. It was necessary to add simultaneously MNNG and o-vanillin to the growth medium. Further investigations were conducted on the induction of ada and umuC genes using ada'-lacZ' and umuC'-lacZ' plasmids. o-Vanillin suppressed the induction of the ada gene by MNNG treatment, but not that of the umuC gene. In fact expression of the umuC gene was induced by lower concentrations of MNNG in the presence of o-vanillin. The results suggest that o-vanillin inhibits induction of the adaptive response, and consequently, the MNNG-induced mutation frequency is increased due to unrepaired O6-methylguanine.

References

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Sep 1, 1989·Mutation Research·K WatanabeY Shirasu
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Citations

Apr 11, 2001·Mutation Research·L R Ferguson
Sep 23, 2003·Nucleic Acids Research·Stephen Durant, Peter Karran
Sep 5, 2002·The British Journal of Dermatology·C-S ShenK Yamanishi
Nov 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jienny LeeJae-Young Song
Jul 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sang Yeol LeeJongsung Lee
Sep 21, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·P SertznigM Megahed
Apr 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M Sasson, A D Krain

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