Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis

Arthritis and Rheumatism
D R ClemmonsRobert Karr

Abstract

The complement component C1s is present in dog joint fluid in an activated state. Since C1s degrades insulin-like growth factor binding protein 5 (IGFBP-5), we undertook to determine whether inhibiting C1s in joint fluid would result in an increase in the amount of intact IGFBP-5 and IGF-1 in cartilage and joint fluid, and whether C1s inhibition would be associated with a reduction in cartilage destruction during the development of osteoarthritis (OA). Twenty-two dogs were randomized to 3 treatment groups. All dogs underwent anterior cruciate ligament transection and were exercised. Dogs received 1 of 3 treatments: buffer alone (controls; n = 6); PB-145, a peptide derived from the sequence of antithrombin III (n = 9); and pentosan polysulfate (PPS; n = 7). PB-145 or saline was injected into the joint space 3 times per week for 3 weeks. PPS was injected intramuscularly weekly for 3 weeks. Joint histology showed preservation of chondrocytes and a smooth joint surface in the animals treated with PB-145 and PPS. Mankin scoring showed statistically significant reductions in joint destruction with PB-145 and PPS treatments (P < 0.01) compared with buffer control. Mean active collagenase concentrations were decreased by these two trea...Continue Reading

References

Dec 1, 1979·Endocrinology·C A StuartH E Lebovitz
Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G H TeschA C Herington
Jan 1, 1989·Arthritis and Rheumatism·J SchalkwijkL B van de Putte
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S B TrippelH J Mankin
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M L DavenportL E Underwood
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N L SchlechterC S Nicoll
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A SettonD S Howell
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A SettonD S Howell
Sep 1, 1996·Arthritis and Rheumatism·J K FernihoughJ M Holly
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D D DeanD S Howell
Apr 30, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Martel-PelletierJ P Pelletier
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K SjögrenC Ohlsson
Feb 22, 2000·The Journal of Biological Chemistry·N R BhaktaT I Morales

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Citations

Aug 15, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rui ZhangJianfeng Yao
Apr 26, 2003·Trends in Endocrinology and Metabolism : TEM·R Clay Bunn, John L Fowlkes
Dec 2, 2009·BMC Musculoskeletal Disorders·Ginette TardifJohanne Martel-Pelletier
Apr 5, 2007·Arthritis Research & Therapy·Reuben GobezieDavid M Lee
Aug 13, 2013·BioMed Research International·Yubo SunEdward N Hanley
Sep 4, 2014·Current Rheumatology Reports·Henning Madry, Magali Cucchiarini
Nov 22, 2013·Arthritis Research & Therapy·Ginette TardifJohanne Martel-Pelletier
Apr 5, 2013·BioMed Research International·Yubo SunHelen E Gruber
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Robert Dinser
Mar 18, 2016·Journal of Zhejiang University. Science. B·Bin XuFu-xing Pei
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Charles W Denko, Charles J Malemud
Jul 23, 2011·Biochimica Et Biophysica Acta·Linda Troeberg, Hideaki Nagase
Oct 22, 2008·Osteoarthritis and Cartilage·W H BusbyD R Clemmons
Jan 31, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Abdul Haseeb, Tariq M Haqqi
Jan 14, 2017·International Journal of Molecular Sciences·Sara CheleschiAntonella Fioravanti
Feb 12, 2004·Arthritis and Rheumatism·Malini SenDennis A Carson
Jul 1, 2017·The Open Rheumatology Journal·Yubo SunEdward N Hanley
Mar 11, 2006·The Biochemical Journal·James BeattieDavid J Flint
Oct 1, 2011·International Journal of Immunopathology and Pharmacology·O GalassoG Gasparini
Oct 18, 2020·Molecular and Cellular Endocrinology·Manisha DixitShoshana Yakar

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