PMID: 7547077Jan 1, 1994Paper

Inhibition of interferon-gamma and interleukin-2 production from lymphocytes stimulated with food antigens by an anti-allergic drug, Tranilast, in patients with food-sensitive atopic dermatitis

Biotherapy
N KondoT Orii

Abstract

N(3',4'-dimethoxycinnamoyl) anthranilic acid (Tranilast) inhibits antibody-mediated hypersensitivity reactions, and is an effective drug for patients with bronchial asthma or allergic rhinitis. Interferon-gamma (IFN-gamma) production of ovalbumin (OA)-stimulated peripheral blood mononuclear cells (PBMCs) from hen's egg-sensitive patients with atopic dermatitis (AD) was significantly higher than those of healthy controls. Tranilast inhibited this IFN-gamma production. Moreover, interleukin-2 (IL-2) production of OA-stimulated PBMCs from hen's egg-sensitive patients with AD was also inhibited by Tranilast. Our results suggest that Tranilast can be used to the patients with food sensitive AD.

References

May 1, 1976·The Journal of Allergy and Clinical Immunology·A KodaK Sakamoto
Aug 1, 1990·The Journal of Allergy and Clinical Immunology·N KondoT Orii
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Feb 1, 1984·The Journal of Allergy and Clinical Immunology·J M Hanifin
Feb 1, 1993·The Journal of Allergy and Clinical Immunology·N KondoT Orii

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Citations

Jul 25, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D E CampbellA S Kemp
Mar 15, 2007·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Masashi KondoNaomi Kondo
Jan 31, 2014·Fibrogenesis & Tissue Repair·Kristy SwiderskiGordon S Lynch
Dec 20, 2005·The Journal of Dermatology·Hiromi TsuboiKensei Katsuoka
Sep 15, 2020·The Cochrane Database of Systematic Reviews·Ratree SawangjitNathorn Chaiyakunapruk
Aug 2, 2003·The British Journal of Dermatology·F IwaoH Shimizu

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