Inhibition of interleukin-2 secretion by factor VIII concentrates: a possible cause of immunosuppression in haemophiliacs

British Journal of Haematology
R ThorpeT W Barrowcliffe

Abstract

The inhibitory effect of factor VIII concentrate products on IL-2 secretion by human T-cells was investigated. The six products used widely in the U.K. showed very different activities varying from almost total inhibition to no significant effect. There appeared to be no obvious relationship between inhibitory activity and protein composition but factor VIII itself was not responsible for the effect as affinity purified products were entirely non-inhibitory. The two wet-heated products were most inhibitory whereas dry-heated products were less inhibitory or non-inhibitory. However, a wet-heated version of a non-inhibitory dry-heated product was also non-inhibitory, suggesting that the composition of the concentrate rather than anti-viral treatment is important for immunosuppressive activity. A product treated by the solvent/detergent procedure showed considerable inhibitory activity. Immunoglobulin and albumin products did not inhibit IL-2 secretion to any significant extent, but factor IX concentrates were inhibitory. We suggest that inhibition of IL-2 secretion by factor VIII concentrates may be related to the immunosuppression observed in haemophiliacs treated with high dose factor VIII products and that our results should b...Continue Reading

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Citations

Nov 1, 1992·British Journal of Haematology·M WadhwaR Thorpe
Sep 1, 1992·British Journal of Haematology·A BatchelorC A Ludlam
Oct 1, 1991·British Journal of Haematology·R MadhokG D Lowe
Dec 22, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M Teitel
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Oct 16, 1999·British Journal of Haematology·H J PearsonC M Steel
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·K Hoots, D Canty
Dec 3, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·A B GrossetG M Rodgers
Jul 6, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·A GringeriUNKNOWN RITS-FITNHES Study Group
Aug 6, 2011·Journal of Thrombosis and Thrombolysis·Massimo Franchini, Giuseppe Lippi
Jul 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·K J PasiF G Hill
Sep 1, 1991·Annals of Hematology·E D Gomperts
Mar 10, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·M V Ragni
Jul 14, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·C BalkanY Aydinok
Jan 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·S V Seremetis
Apr 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·K J Pasi
May 1, 1992·Progress in Cardiovascular Diseases·J FareedR Pifarre

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