Inhibition of interleukin-6-activated janus kinases/signal transducers and activators of transcription but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats

Critical Care Medicine
Pei-Ra LingB R Bistrian

Abstract

Endotoxin-induced cytokines, such as interleukin-6, mediate systemic inflammatory responses through multiple cellular signaling pathways. Interleukin-6 is also responsible for the synthesis of acute phase proteins. Recent studies have shown that endotoxin can inhibit signal transducers and activators of transcription (STAT)-3 tyrosine phosphorylation in cultured cells, suggesting that this effect may limit the synthesis of acute phase proteins. The purpose of this study was to examine the effects of endotoxin on interleukin-6 activation of STATs and mitogen-activated protein (MAP) kinase pathways in rat liver in vivo. Controlled laboratory study. Medical school laboratory. Specific pathogen-free male Sprague Dawley rats. Under anesthesia, interleukin-6 was injected into the portal vein of rats 4 hrs after the bolus intravenous administration of endotoxin (1 mg/kg) or saline. The effects of interleukin-6 on key intermediates in early steps of the interleukin-6 signaling pathway, including janus kinase-1, gp 130, the interleukin-6 receptor, STAT1, and STAT3, were examined in both saline and endotoxin-treated rats. In endotoxin-treated rats, there was significant inhibition of interleukin-6 activation of janus kinase-1, gp 130, th...Continue Reading

References

Jan 1, 1988·Cell Motility and the Cytoskeleton·S H ZigmondM Carson
May 1, 1987·Metabolism: Clinical and Experimental·C H Lang, J A Spitzer
Jan 1, 1994·Annual Review of Cell Biology·P van der GeerR A Lindberg
Nov 1, 1994·Journal of Leukocyte Biology·H BluethmannP Koebel
Jul 1, 1994·The Journal of Surgical Research·K KoikeV M Peterson
Jan 28, 1994·Cell·T KishimotoS Akira
Apr 19, 1996·The Journal of Biological Chemistry·D ZhangI Kushner
Mar 1, 1997·The Journal of Pathology·H Moshage
Jun 27, 1997·Cell·M L AvantaggiatiK Kelly
Sep 18, 1997·Nutrition·R ChioléroL Tappy
Oct 6, 1997·Cellular Signalling·A PaulR Plevin
Mar 20, 1998·International Reviews of Immunology·T Hirano
May 20, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·H R Chang, B Bistrian
May 20, 1998·Biochemical and Biophysical Research Communications·N NyuiM Ishii
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T K SenguptaL B Ivashkiv
Oct 24, 1998·Domestic Animal Endocrinology·J L SartinC D McMahon
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·M H Heim
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C W LushP R Kvietys
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F NomuraS Akira
Apr 25, 2000·World Journal of Surgery·D W Wilmore
May 12, 2000·Critical Care Medicine·A OberholzerL L Moldawer
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A E MedvedevS N Vogel
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C H LangT C Vary

❮ Previous
Next ❯

Citations

Mar 21, 2002·Critical Care Medicine·Robert N Cooney, Gladys Yumet
Apr 21, 2009·Metabolism: Clinical and Experimental·Pei-Ra Ling, Bruce R Bistrian
Sep 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pei-Ra LingBruce R Bistrian
Apr 22, 2005·American Journal of Physiology. Cell Physiology·Rachel J WebbGeraint M H Thomas
Nov 29, 2005·International Journal of Experimental Pathology·Giovana R ThomasJacinto Regalado
Dec 1, 2015·Frontiers in Microbiology·Marie-Josée NadeauRenée N Douville

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.