PMID: 16629169Apr 25, 2006Paper

Inhibition of iron and copper uptake by iron, copper and zinc

Biological Research
M ArredondoManuel Olivares

Abstract

Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical characteristics and uptake process can take place. The consequences of these interactions may depend on the relative concentrations of the nutrients. In this work, we measure the effects of increasing concentrations of iron, zinc, and copper on iron and copper uptake in Caco-2 cells. Intracellular Fe or Cu levels were affected by incubating with increased concentrations of metals. However, when the cells already had different intracellular metal concentration, the uptake of Fe or Cu was nor affected. In competition studies, we showed that Cu and Zn inhibited Fe uptake, and while Fe inhibited Cu uptake, Zn did not. When the three metals were given together (1:1:1 ratio), Fe or Cu uptake was inhibited approximately 40%. These results point to a potential risk in the absorption and bioavailability of these minerals by the presence of other minerals in the diet. This aspect must be considered in food supplementation and fortification programs.

Citations

Oct 5, 2010·Journal of Neural Transmission·Francisco J GómezMarco T Núñez
Aug 14, 2010·Obesity Surgery·Agnès SalléVincent Rohmer
May 17, 2008·Biological Trace Element Research·Gerardo WeisstaubMagdalena Araya
Oct 13, 2009·Biological Trace Element Research·Manuel OlivaresManuel Ruz
Feb 3, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Manuel OlivaresDaniel López de Romaña
May 10, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Alexey A TinkovAlexandr A Nikonorov
Dec 23, 2009·FEBS Letters·Sara BalesariaSurjit K S Srai
Jun 17, 2014·Nutrients·Ceres Mattos Della LuciaHelena Maria Pinheiro Sant'Ana
Feb 15, 2011·Toxicology and Applied Pharmacology·Andrew D MonnotWei Zheng
Mar 1, 2014·Toxicology Letters·Constantinos GitrowskiRichard D Handy
Jun 5, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yanzhu ZhuLiguang Miao
Jul 16, 2013·Plant Science : an International Journal of Experimental Plant Biology·Guilherme Amaral de SouzaLi Li
Jan 26, 2010·Free Radical Biology & Medicine·Sreenivasulu KilariK Madhavan Nair
Mar 2, 2018·Food & Function·Fabiola Moreno-OlivasGretchen J Mahler
Mar 11, 2016·The Journal of Nutrition·Janet C KingDaniel J Raiten
Jun 26, 2009·The American Journal of Clinical Nutrition·Sunita TanejaMaharaj Kishan Bhan
Jun 10, 2016·The Cochrane Database of Systematic Reviews·Dheeraj ShahJuan Pablo Peña-Rosas
Jan 8, 2009·British Journal of Cancer·A BohlkenG M Marshall
Aug 2, 2007·The British Journal of Nutrition·Ruth DanzeisenHarry J McArdle
Sep 18, 2007·Biological Trace Element Research·M OlivaresM Ruz
Apr 23, 2010·Journal of Pediatric Gastroenterology and Nutrition·Mariana A JanjeticJosé R Boccio
Aug 7, 2019·Journal of Dietary Supplements·Cara L Frankenfeld, Taylor C Wallace
Aug 21, 2019·Environmental Geochemistry and Health·Alexys Giorgia Friol BoimLuís Reynaldo Ferracciú Alleoni
Feb 6, 2020·International Journal of Molecular Sciences·Sara M HancockPaul A Adlard
Sep 2, 2019·Biological Trace Element Research·Gurseen RakhraSom Nath Singh
Jul 7, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S GuptaN M Lowe
May 8, 2019·Translational Animal Science·Henrique S CeminJames L Usry
Dec 31, 2015·Biological Trace Element Research·Manuel OlivaresFernando Pizarro
May 19, 2017·Ecology and Evolution·Deli WangKunshan Gao
Aug 31, 2019·Metallomics : Integrated Biometal Science·Man Long Kwok, King Ming Chan
Feb 25, 2019·In Vitro Cellular & Developmental Biology. Animal·Charles O'DohertyMartin Clynes
Nov 29, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dawid MadejJoanna Kaluza
Nov 18, 2020·Antioxidants·Theresa WolframAnna P Kipp
Jul 16, 2010·Food and Nutrition Bulletin·Mary Serdula, UNKNOWN Second Technical Workshop on Wheat Flour Fortification
May 29, 2021·Klinicheskaia laboratornaia diagnostika·Tatyana Nikolaevna PogorelovaL V Kaushanskaya

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